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TargetMuscarinic acetylcholine receptor M2
LigandBDBM50064176
Substrate/Competitorn/a
Meas. Tech.ChEMBL_138518
Kd 19.5±n/a nM
Citation Melchiorre CQuaglia WPicchio MTGiardinà DBrasili LAngeli P Structure-activity relationships among methoctramine-related polymethylene tetraamines. Chain-length and substituent effects on M-2 muscarinic receptor blocking activity. J Med Chem 32:79-84 (1989) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
Muscarinic acetylcholine receptor M2
Name:Muscarinic acetylcholine receptor M2 and M5
Synonyms:CHRM2 | Cholinergic, muscarinic M2 | RecName: Full=Muscarinic acetylcholine receptor M2
Type:GPCR
Mol. Mass.:51730.61
Organism:Homo sapiens (Human)
Description:P08172
Residue:466
Sequence:
MNNSTNSSNNSLALTSPYKTFEVVFIVLVAGSLSLVTIIGNILVMVSIKVNRHLQTVNNY
FLFSLACADLIIGVFSMNLYTLYTVIGYWPLGPVVCDLWLALDYVVSNASVMNLLIISFD
RYFCVTKPLTYPVKRTTKMAGMMIAAAWVLSFILWAPAILFWQFIVGVRTVEDGECYIQF
FSNAAVTFGTAIAAFYLPVIIMTVLYWHISRASKSRIKKDKKEPVANQDPVSPSLVQGRI
VKPNNNNMPSSDDGLEHNKIQNGKAPRDPVTENCVQGEEKESSNDSTSVSAVASNMRDDE
ITQDENTVSTSLGHSKDENSKQTCIRIGTKTPKSDSCTPTNTTVEVVGSSGQNGDEKQNI
VARKIVKMTKQPAKKKPPPSREKKVTRTILAILLAFIITWAPYNVMVLINTFCAPCIPNT
VWTIGYWLCYINSTINPACYALCNATFKKTFKHLLMCHYKNIGATR
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  Blast E-value cutoff:
BDBM50064176
n/a
NameBDBM50064176
Synonyms:CHEMBL27673 | CHEMBL500996 | METHOCTRAMINE | N,N''-Bis-[6-(2-methoxy-benzylamino)-hexyl]-octane-1,8-diamine | N1,N8-bis(6-(2-methoxybenzylamino)hexyl)octane-1,8-diamine
TypeSmall organic molecule
Emp. Form.C36H62N4O2
Mol. Mass.582.9031
SMILESCOc1ccccc1CNCCCCCCNCCCCCCCCNCCCCCCNCc1ccccc1OC
Structure
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