| Reaction Details |
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 | Report a problem with these data |
| Target | Neutrophil elastase |
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| Ligand | BDBM50406237 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_21101 (CHEMBL633695) |
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| Ki | 1.995E1±n/a nM |
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| KON | 1.995E6 M-1s-1 |
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| Citation |  Krantz, A; Spencer, RW; Tam, TF; Liak, TJ; Copp, LJ; Thomas, EM; Rafferty, SP Design and synthesis of 4H-3,1-benzoxazin-4-ones as potent alternate substrate inhibitors of human leukocyte elastase. J Med Chem33:464-79 (1990) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| Neutrophil elastase |
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| Name: | Neutrophil elastase |
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| Synonyms: | Bone marrow serine protease | Chymotrypsin | Coagulation factor X | ELA2 | ELANE | ELNE_HUMAN | Elastase | Elastase-2 | HLE | Human leukocyte elastase | Leukocyte elastase | Leukocyte elastase (HLE) | Medullasin | Neutrophil elastase | Neutrophil elastase (HNE) | Neutrophil elastase (NE) | PMN elastase | Thrombin | Trypsin |
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| Type: | Enzyme |
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| Mol. Mass.: | 28532.38 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P08246 |
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| Residue: | 267 |
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| Sequence: | MTLGRRLACLFLACVLPALLLGGTALASEIVGGRRARPHAWPFMVSLQLRGGHFCGATLI
APNFVMSAAHCVANVNVRAVRVVLGAHNLSRREPTRQVFAVQRIFENGYDPVNLLNDIVI
LQLNGSATINANVQVAQLPAQGRRLGNGVQCLAMGWGLLGRNRGIASVLQELNVTVVTSL
CRRSNVCTLVRGRQAGVCFGDSGSPLVCNGLIHGIASFVRGGCASGLYPDAFAPVAQFVN
WIDSIIQRSEDNPCPHPRDPDPASRTH
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| BDBM50406237 |
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| n/a |
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| Name | BDBM50406237 |
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| Synonyms: | CHEMBL343003 |
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| Type | Small organic molecule |
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| Emp. Form. | C12H13NO2S |
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| Mol. Mass. | 235.302 |
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| SMILES | CCSc1nc2cc(CC)ccc2c(=O)o1 |
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| Structure | 
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