Reaction Details |
| Report a problem with these data |
Target | Neutrophil elastase |
---|
Ligand | BDBM50406266 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_21101 (CHEMBL633695) |
---|
Ki | 7.943E0±n/a nM |
---|
KOFF | 2.239E-2 s-1 |
---|
KON | 2.884E6 M-1s-1 |
---|
Citation | Krantz, A; Spencer, RW; Tam, TF; Liak, TJ; Copp, LJ; Thomas, EM; Rafferty, SP Design and synthesis of 4H-3,1-benzoxazin-4-ones as potent alternate substrate inhibitors of human leukocyte elastase. J Med Chem33:464-79 (1990) [PubMed] |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Neutrophil elastase |
---|
Name: | Neutrophil elastase |
Synonyms: | Bone marrow serine protease | Chymotrypsin | Coagulation factor X | ELA2 | ELANE | ELNE_HUMAN | Elastase | Elastase-2 | HLE | Human leukocyte elastase | Leukocyte elastase | Leukocyte elastase (HLE) | Medullasin | Neutrophil elastase | Neutrophil elastase (HNE) | Neutrophil elastase (NE) | PMN elastase | Thrombin | Trypsin |
Type: | Enzyme |
Mol. Mass.: | 28532.38 |
Organism: | Homo sapiens (Human) |
Description: | P08246 |
Residue: | 267 |
Sequence: | MTLGRRLACLFLACVLPALLLGGTALASEIVGGRRARPHAWPFMVSLQLRGGHFCGATLI
APNFVMSAAHCVANVNVRAVRVVLGAHNLSRREPTRQVFAVQRIFENGYDPVNLLNDIVI
LQLNGSATINANVQVAQLPAQGRRLGNGVQCLAMGWGLLGRNRGIASVLQELNVTVVTSL
CRRSNVCTLVRGRQAGVCFGDSGSPLVCNGLIHGIASFVRGGCASGLYPDAFAPVAQFVN
WIDSIIQRSEDNPCPHPRDPDPASRTH
|
|
|
BDBM50406266 |
---|
n/a |
---|
Name | BDBM50406266 |
Synonyms: | CHEMBL358112 |
Type | Small organic molecule |
Emp. Form. | C11H11NO2S |
Mol. Mass. | 221.276 |
SMILES | CC(C)Sc1nc2ccccc2c(=O)o1 |
Structure |
|