Reaction Details |
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Target | Reverse transcriptase/RNaseH |
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Ligand | BDBM2243 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_195671 (CHEMBL800744) |
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IC50 | 172±n/a nM |
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Citation | Hoffman, JM; Smith, AM; Rooney, CS; Fisher, TE; Wai, JS; Thomas, CM; Bamberger, DL; Barnes, JL; Williams, TM; Jones, JH Synthesis and evaluation of 2-pyridinone derivatives as HIV-1-specific reverse transcriptase inhibitors. 4. 3-[2-(Benzoxazol-2-yl)ethyl]-5-ethyl-6-methylpyridin-2(1H)-one and analogues. J Med Chem36:953-66 (1993) [PubMed] |
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More Info.: | Get all data from this article, Assay Method |
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Reverse transcriptase/RNaseH |
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Name: | Reverse transcriptase/RNaseH |
Synonyms: | HIV-1 Reverse Transcriptase RNase H | Human immunodeficiency virus type 1 reverse transcriptase | Reverse transcriptase/RNaseH |
Type: | PROTEIN |
Mol. Mass.: | 65229.15 |
Organism: | Human immunodeficiency virus 1 |
Description: | ChEMBL_1473730 |
Residue: | 566 |
Sequence: | PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKRKSVTVLDVGDAYFSVPL
DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI
YQYMDDLYVGSDLEIGQHRTKIEELRQHLLRWGLTTPDKKHQKEPPFLWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIRVRQLCKLLRGTKALTEVIPLTEEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLRTGKYARMRGA
HTNDVKQLTEAVQKITTESIVIWGKTPKFKLPIQKETWETWWTEYWQATWIPEWEFVNTP
PLVKLWYQLEKEPIVGAETFYVDGAANRETKLGKAGYVTNRGRQKVVTLTDTTNQKTELQ
AIYLALQDSGLEVNIVTDSQYALGIIQAQPDQSESELVNQIIEQLIKKEKVYLAWVPAHK
GIGGNEQVDKLVSAGIRKVLFLDGID
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BDBM2243 |
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n/a |
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Name | BDBM2243 |
Synonyms: | 2-Pyridinone derivative 23 | 3-[2-(6-Methylbenzoxazol-2-yl)ethyl]-5-ethyl-6-methylpyridin-2(1H)-one | 5-ethyl-6-methyl-3-[2-(6-methyl-1,3-benzoxazol-2-yl)ethyl]-1,2-dihydropyridin-2-one | CHEMBL177256 |
Type | Small organic molecule |
Emp. Form. | C18H20N2O2 |
Mol. Mass. | 296.3636 |
SMILES | CCc1cc(CCc2nc3ccc(C)cc3o2)c(=O)[nH]c1C |
Structure |
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