| Reaction Details |
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 | Report a problem with these data |
| Target | Reverse transcriptase/RNaseH |
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| Ligand | BDBM2261 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_195671 (CHEMBL800744) |
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| IC50 | 1250±n/a nM |
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| Citation |  Hoffman, JM; Smith, AM; Rooney, CS; Fisher, TE; Wai, JS; Thomas, CM; Bamberger, DL; Barnes, JL; Williams, TM; Jones, JH Synthesis and evaluation of 2-pyridinone derivatives as HIV-1-specific reverse transcriptase inhibitors. 4. 3-[2-(Benzoxazol-2-yl)ethyl]-5-ethyl-6-methylpyridin-2(1H)-one and analogues. J Med Chem36:953-66 (1993) [PubMed] |
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| More Info.: | Get all data from this article, Assay Method |
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| |
| Reverse transcriptase/RNaseH |
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| Name: | Reverse transcriptase/RNaseH |
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| Synonyms: | HIV-1 Reverse Transcriptase RNase H | Human immunodeficiency virus type 1 reverse transcriptase | Reverse transcriptase/RNaseH |
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| Type: | PROTEIN |
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| Mol. Mass.: | 65229.15 |
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| Organism: | Human immunodeficiency virus 1 |
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| Description: | ChEMBL_1473730 |
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| Residue: | 566 |
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| Sequence: | PISPIETVPVKLKPGMDGPKVKQWPLTEEKIKALVEICTEMEKEGKISKIGPENPYNTPV
FAIKKKDSTKWRKLVDFRELNKRTQDFWEVQLGIPHPAGLKKRKSVTVLDVGDAYFSVPL
DEDFRKYTAFTIPSINNETPGIRYQYNVLPQGWKGSPAIFQSSMTKILEPFRKQNPDIVI
YQYMDDLYVGSDLEIGQHRTKIEELRQHLLRWGLTTPDKKHQKEPPFLWMGYELHPDKWT
VQPIVLPEKDSWTVNDIQKLVGKLNWASQIYPGIRVRQLCKLLRGTKALTEVIPLTEEAE
LELAENREILKEPVHGVYYDPSKDLIAEIQKQGQGQWTYQIYQEPFKNLRTGKYARMRGA
HTNDVKQLTEAVQKITTESIVIWGKTPKFKLPIQKETWETWWTEYWQATWIPEWEFVNTP
PLVKLWYQLEKEPIVGAETFYVDGAANRETKLGKAGYVTNRGRQKVVTLTDTTNQKTELQ
AIYLALQDSGLEVNIVTDSQYALGIIQAQPDQSESELVNQIIEQLIKKEKVYLAWVPAHK
GIGGNEQVDKLVSAGIRKVLFLDGID
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|
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| BDBM2261 |
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| n/a |
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| Name | BDBM2261 |
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| Synonyms: | 2-Pyridinone derivative 41 | 3-[(1,3-benzoxazol-2-ylamino)methyl]-5-ethyl-6-methyl-1,2-dihydropyridin-2-one | 3-{[(Benzoxazol-2-yl)amino]methyl}-5-ethyl-6-methylpyridin-2(1H)-one | CHEMBL175089 |
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| Type | Small organic molecule |
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| Emp. Form. | C16H17N3O2 |
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| Mol. Mass. | 283.3251 |
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| SMILES | CCc1cc(CNc2nc3ccccc3o2)c(=O)[nH]c1C |
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| Structure | 
|
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