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TargetDihydrofolate Reductase (DHFR)
LigandBDBM50291768
Substrate/Competitorn/a
Meas. Tech.ChEMBL_52999
Ki 3.8±n/a nM
Citation Marlowe CKSelassie CDSanti DV Quantitative structure-activity relationships of the inhibition of Pneumocystis carinii dihydrofolate reductase by 4,6-diamino-1,2-dihydro-2,2-dimethyl-1-(X-phenyl)-s-triazines. J Med Chem 38:967-72 (1995) [PubMed]
More Info.:Get all data from this article,  Assay Method
 
Dihydrofolate Reductase (DHFR)
Name:Bacterial dihydrofolate reductase
Synonyms:Bacterial dihydrofolate reductase | Tetrahydrofolate dehydrogenase
Type:Enzyme
Mol. Mass.:17991.61
Organism:Escherichia coli
Description:E. coli DHFR was expressed in BL21, and purified to homogeneity.
Residue:159
Sequence:
MISLIAALAVDRVIGMENAMPWNLPADLAWFKRNTLNKPVIMGRHTWESIGRPLPGRKNI
ILSSQPGTDDRVTWVKSVDEAIAACGDVPEIMVIGGGRVYEQFLPKAQKLYLTHIDAEVE
GDTHFPDYEPDDWESVFSEFHDADAQNSHSYCFEILERR
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BDBM50291768
n/a
NameBDBM50291768
Synonyms:6,6-Dimethyl-1-(3-phenylselanylmethyl-phenyl)-1,6-dihydro-[1,3,5]triazine-2,4-diamine | CHEMBL20224
TypeSmall organic molecule
Emp. Form.C18H21N5Se
Mol. Mass.386.35
SMILESCC1(C)N=C(N)N=C(N)N1c1cccc(C[Se]c2ccccc2)c1 |t:3,6|
Structure
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