Reaction Details |
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Target | Peptidyl-prolyl cis-trans isomerase FKBP1A |
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Ligand | BDBM50408104 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_66276 (CHEMBL857528) |
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Ki | 200±n/a nM |
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Citation | Dragovich, PS; Barker, JE; French, J; Imbacuan, M; Kalish, VJ; Kissinger, CR; Knighton, DR; Lewis, CT; Moomaw, EW; Parge, HE; Pelletier, LA; Prins, TJ; Showalter, RE; Tatlock, JH; Tucker, KD; Villafranca, JE Structure-based design of novel, urea-containing FKBP12 inhibitors. J Med Chem39:1872-84 (1996) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Peptidyl-prolyl cis-trans isomerase FKBP1A |
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Name: | Peptidyl-prolyl cis-trans isomerase FKBP1A |
Synonyms: | 12 kDa FK506-binding protein | 12 kDa FKBP | FK506-binding protein 1A | FK506-binding protein 1A (FKBP12) | FKB1A_HUMAN | FKBP-12 | FKBP-1A | FKBP1 | FKBP12 | FKBP1A | Immunophilin FKBP12 | PPIase | PPIase FKBP1A | Peptidyl-prolyl cis-trans isomerase (FKBP) | Rotamase | RyR1/FKBP12 | mTOR/FKBP12A/FKBP12B |
Type: | Isomerase |
Mol. Mass.: | 11953.09 |
Organism: | Homo sapiens (Human) |
Description: | P62942 |
Residue: | 108 |
Sequence: | MGVQVETISPGDGRTFPKRGQTCVVHYTGMLEDGKKFDSSRDRNKPFKFMLGKQEVIRGW
EEGVAQMSVGQRAKLTISPDYAYGATGHPGIIPPHATLVFDVELLKLE
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BDBM50408104 |
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n/a |
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Name | BDBM50408104 |
Synonyms: | CHEMBL292238 |
Type | Small organic molecule |
Emp. Form. | C28H36N2O4 |
Mol. Mass. | 464.5964 |
SMILES | CC1(CNC(=O)N2CCCC[C@H]2C(=O)OCc2cccc(Oc3ccccc3)c2)CCCCC1 |
Structure |
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