| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Alpha-2B adrenergic receptor |
|---|
| Ligand | BDBM50408199 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_33508 (CHEMBL647005) |
|---|
| Ki | 8600±n/a nM |
|---|
| Citation |  Elworthy, TR; Ford, AP; Bantle, GW; Morgans, DJ; Ozer, RS; Palmer, WS; Repke, DB; Romero, M; Sandoval, L; Sjogren, EB; Talamás, FX; Vazquez, A; Wu, H; Arredondo, NF; Blue, DR; DeSousa, A; Gross, LM; Kava, MS; Lesnick, JD; Vimont, RL; Williams, TJ; Zhu, QM; Pfister, JR; Clarke, DE N-arylpiperazinyl-N'-propylamino derivatives of heteroaryl amides as functional uroselective alpha 1-adrenoceptor antagonists. J Med Chem40:2674-87 (1997) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Alpha-2B adrenergic receptor |
|---|
| Name: | Alpha-2B adrenergic receptor |
|---|
| Synonyms: | ADA2B_RAT | Adra2b | Adrenergic receptor alpha | Adrenergic receptor alpha-2 | Alpha-2B adrenergic receptor | Alpha-2B adrenoceptor | Alpha-2B adrenoreceptor | adrenergic Alpha2B |
|---|
| Type: | Enzyme Catalytic Domain |
|---|
| Mol. Mass.: | 50379.83 |
|---|
| Organism: | NEONATAL RAT |
|---|
| Description: | adrenergic Alpha2B ADRA2B NEONATAL RAT::P19328 |
|---|
| Residue: | 453 |
|---|
| Sequence: | MSGPTMDHQEPYSVQATAAIASAITFLILFTIFGNALVILAVLTSRSLRAPQNLFLVSLA
AADILVATLIIPFSLANELLGYWYFWRAWCEVYLALDVLFCTSSIVHLCAISLDRYWAVS
RALEYNSKRTPRRIKCIILTVWLIAAVISLPPLIYKGDQRPEPRGLPQCELNQEAWYILA
SSIGSFFAPCLIMILVYLRIYVIAKRSHCRGLGAKRGSGEGESKKPQPVAGGVPTSAKVP
TLVSPLSSVGEANGHPKPPREKEEGETPEDPEARALPPTWSALPRSGQGQKKGTSGATAE
EGDEEDEEEVEECEPQTLPASPASVCNPPLQQPQTSRVLATLRGQVLLGKNVGVASGQWW
RRRTQLSREKRFTFVLAVVIGVFVVCWFPFFFSYSLGAICPQHCKVPHGLFQFFFWIGYC
NSSLNPVIYTVFNQDFRRAFRRILCRPWTQTGW
|
|
|
|---|
| BDBM50408199 |
|---|
| n/a |
|---|
| Name | BDBM50408199 |
|---|
| Synonyms: | CHEMBL88160 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C26H34F3N7O2 |
|---|
| Mol. Mass. | 533.5891 |
|---|
| SMILES | CN(C)C(=O)c1cnc2n(C)nc(C)c2c1NCCCN1CCN(CC1)c1ccccc1OCC(F)(F)F |
|---|
| Structure | 
|
|---|
Search and Browse
