| Reaction Details |
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 | Report a problem with these data |
| Target | Cathepsin K |
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| Ligand | BDBM50066650 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_48328 (CHEMBL663317) |
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| Ki | 22±n/a nM |
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| Citation |  LaLonde, JM; Zhao, B; Smith, WW; Janson, CA; DesJarlais, RL; Tomaszek, TA; Carr, TJ; Thompson, SK; Oh, HJ; Yamashita, DS; Veber, DF; Abdel-Meguid, SS Use of papain as a model for the structure-based design of cathepsin K inhibitors: crystal structures of two papain-inhibitor complexes demonstrate binding to S'-subsites. J Med Chem41:4567-76 (1998) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cathepsin K |
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| Name: | Cathepsin K |
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| Synonyms: | CATK_HUMAN | CTSK | CTSO | CTSO2 | Cathepsin O | Cathepsin O2 | Cathepsin X |
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| Type: | Enzyme |
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| Mol. Mass.: | 36975.68 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P43235 |
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| Residue: | 329 |
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| Sequence: | MWGLKVLLLPVVSFALYPEEILDTHWELWKKTHRKQYNNKVDEISRRLIWEKNLKYISIH
NLEASLGVHTYELAMNHLGDMTSEEVVQKMTGLKVPLSHSRSNDTLYIPEWEGRAPDSVD
YRKKGYVTPVKNQGQCGSCWAFSSVGALEGQLKKKTGKLLNLSPQNLVDCVSENDGCGGG
YMTNAFQYVQKNRGIDSEDAYPYVGQEESCMYNPTGKAAKCRGYREIPEGNEKALKRAVA
RVGPVSVAIDASLTSFQFYSKGVYYDESCNSDNLNHAVLAVGYGIQKGNKHWIIKNSWGE
NWGNKGYILMARNKNNACGIANLASFPKM
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| BDBM50066650 |
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| n/a |
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| Name | BDBM50066650 |
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| Synonyms: | 1,3-BIS[[N-[(PHENYLMETHOXY)CARBONYL]-L-LEUCYL]AMINO]-2-PROPANONE | CHEMBL281540 | {(S)-1-[3-((S)-2-Benzyloxycarbonylamino-4-methyl-pentanoylamino)-2-oxo-propylcarbamoyl]-3-methyl-butyl}-carbamic acid benzyl ester | {1-[3-(2-Benzyloxycarbonylamino-4-methyl-pentanoylamino)-2-oxo-propylcarbamoyl]-3-methyl-butyl}-carbamic acid benzyl ester |
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| Type | Small organic molecule |
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| Emp. Form. | C31H42N4O7 |
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| Mol. Mass. | 582.6878 |
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| SMILES | CC(C)C[C@H](NC(=O)OCc1ccccc1)C(=O)NCC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)OCc1ccccc1 |
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| Structure | 
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