Ki Summary

Reaction Details

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Target

ATP synthase subunit gamma, mitochondrial

Ligand

BDBM50012957

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_65923 (CHEMBL678318)

IC50

>100000±n/a nM

Citation

Atwal, KS; Wang, P; Rogers, WL; Sleph, P; Monshizadegan, H; Ferrara, FN; Traeger, S; Green, DW; Grover, GJ Small molecule mitochondrial F1F0 ATPase hydrolase inhibitors as cardioprotective agents. Identification of 4-(N-arylimidazole)-substituted benzopyran derivatives as selective hydrolase inhibitors. J Med Chem47:1081-4 (2004) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

ATP synthase subunit gamma, mitochondrial

Name:

ATP synthase subunit gamma, mitochondrial

Synonyms:

ATP5C | ATP5C1 | ATP5F1C | ATPG_BOVIN | F-ATPase gamma subunit

Type:

PROTEIN

Mol. Mass.:

33081.70

Organism:

Bos taurus

Description:

ChEMBL_65923

Residue:

298

Sequence:

MFSRAGVAGLSAWTVQPQWIQVRNMATLKDITRRLKSIKNIQKITKSMKMVAAAKYARAE
RELKPARVYGVGSLALYEKADIKTPEDKKKHLIIGVSSDRGLCGAIHSSVAKQMKSEAAN
LAAAGKEVKIIGVGDKIRSILHRTHSDQFLVTFKEVGRRPPTFGDASVIALELLNSGYEF
DEGSIIFNRFRSVISYKTEEKPIFSLDTISSAESMSIYDDIDADVLRNYQEYSLANIIYY
SLKESTTSEQSARMTAMDNASKNASEMIDKLTLTFNRTRQAVITKELIEIISGAAALD

BDBM50012957

n/a

Name

BDBM50012957

Synonyms:

1-((p-(2-(5-chloro-o-anisamido)ethyl)phenyl)sulfonyl)-3-cyclohexylurea | 1-(p-(2-(5-chloro-2-methoxybenzamido)ethyl)benzenesulfonyl)-3-cyclohexylurea | 5-chloro-N-(2-(4-((((cyclohexylamino)carbonyl)amino)sulfonyl)phenyl)ethyl)-2-methoxybenzamide | 5-chloro-N-(2-{4-[N-(N-cyclohexylcarbamoyl)sulfamoyl]phenyl}ethyl)-2-methoxybenzamide | CHEMBL472 | GLYBURIDE | Glibenclamide | US20230348371, Compound 5

Type

Small organic molecule

Emp. Form.

C23H28ClN3O5S

Mol. Mass.

494.004

SMILES

COc1ccc(Cl)cc1C(=O)NCCc1ccc(cc1)S(=O)(=O)NC(=O)NC1CCCCC1

Structure