| Reaction Details |
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 | Report a problem with these data |
| Target | Potassium voltage-gated channel subfamily KQT member 2 |
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| Ligand | BDBM50410077 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_310664 (CHEMBL838011) |
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| EC50 | 20±n/a nM |
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| Citation |  L'Heureux, A; Martel, A; He, H; Chen, J; Sun, LQ; Starrett, JE; Natale, J; Dworetzky, SI; Knox, RJ; Harden, DG; Weaver, D; Thompson, MW; Wu, YJ (S,E)-N-[1-(3-heteroarylphenyl)ethyl]-3-(2-fluorophenyl)acrylamides: synthesis and KCNQ2 potassium channel opener activity. Bioorg Med Chem Lett15:363-6 (2004) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Potassium voltage-gated channel subfamily KQT member 2 |
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| Name: | Potassium voltage-gated channel subfamily KQT member 2 |
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| Synonyms: | KCNQ2_MOUSE | KQT-like 2 | Kcnq2 | Kqt2 | Potassium channel subunit alpha KvLQT2 | Potassium voltage-gated channel subfamily KQT member 2 | Voltage-gated potassium channel subunit Kv7.2 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 84494.02 |
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| Organism: | Mus musculus |
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| Description: | ChEMBL_990142 |
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| Residue: | 759 |
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| Sequence: | MVQKSRNGGVYPGTSGEKKLKVGFVGLDPGAPDSTRDGALLIAGSEAPKRGSVLSKPRTG
GAGAGKPPKRNAFYRKLQNFLYNVLERPRGWAFIYHAYVFLLVFSCLVLSVFSTIKEYEK
SSEGALYILEIVTIVVFGVEYFVRIWAAGCCCRYRGWRGRLKFARKPFCVIDIMVLIASI
AVLAAGSQGNVFATSALRSLRFLQILRMIRMDRRGGTWKLLGSVVYAHSKELVTAWYIGF
LCLILASFLVYLAEKGENDHFDTYADALWWGLITLTTIGYGDKYPQTWNGRLLAATFTLI
GVSFFALPAGILGSGFALKVQEQHRPKHFEKRRNPAAGLIQSAWRFYATNLSRTDLHSTW
QYYERTVTVPMYRLIPPLNQLELLRNLKSKSGLTFRKEPQPEPSPSQKVSLKDRVFSSPR
GMAAKGKGSPQAQTVRRSPSADQSLDDSPSKVPKSWSFGDRSRTRQAFRIKGAASRQNSE
EASLPGEDIVEDNKSCNCEFVTEDLTPGLKVSIRAVCVMRFLVSKRKFKESLRPYDVMDV
IEQYSAGHLDMLSRIKSLQSRIDMIVGPPPPSTPRDKKYPTKGPTAPSRESPQYSPRVDH
IVGRGPTITDKDRTKGPAETELPEDPSMMGRLGKVEKQVLSMEKKLDFLVSIYTQRMGIP
PAETEAYFGAKEPEPAPPYHSPEDSRDHADKHGCIIKIVRSTSSTGQRNYAAPPAIPPAQ
CPPSTSWQQSHQRHGTSPVGDHGSLVLRLERSAGMMSCH
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| BDBM50410077 |
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| n/a |
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| Name | BDBM50410077 |
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| Synonyms: | CHEMBL180886 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H16ClNO3 |
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| Mol. Mass. | 329.778 |
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| SMILES | C[C@H](NC(=O)\C=C\c1ccccc1Cl)c1ccc2OCOc2c1 |
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| Structure | 
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