| Reaction Details |
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 | Report a problem with these data |
| Target | Histamine H3 receptor |
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| Ligand | BDBM50126888 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_304030 (CHEMBL840208) |
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| Ki | 2.82±n/a nM |
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| Citation |  Dvorak, CA; Apodaca, R; Barbier, AJ; Berridge, CW; Wilson, SJ; Boggs, JD; Xiao, W; Lovenberg, TW; Carruthers, NI 4-phenoxypiperidines: potent, conformationally restricted, non-imidazole histamine H3 antagonists. J Med Chem48:2229-38 (2005) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Histamine H3 receptor |
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| Name: | Histamine H3 receptor |
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| Synonyms: | G-protein coupled receptor 97 | GPCR97 | HH3R | HISTAMINE H3 | HRH3 | HRH3_HUMAN | Histamine H3 receptor (H3) | Histamine H3L | Histamine receptor (H3 and H4) |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 48691.47 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Binding assays were using CHO cells stably expressing hH3R receptors. |
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| Residue: | 445 |
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| Sequence: | MERAPPDGPLNASGALAGEAAAAGGARGFSAAWTAVLAALMALLIVATVLGNALVMLAFV
ADSSLRTQNNFFLLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCTS
SAFNIVLISYDRFLSVTRAVSYRAQQGDTRRAVRKMLLVWVLAFLLYGPAILSWEYLSGG
SSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGAREAA
GPEPPPEAQPSPPPPPGCWGCWQKGHGEAMPLHRYGVGEAAVGAEAGEATLGGGGGGGSV
ASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSFTQRFRLSRDRKVAKSL
AVIVSIFGLCWAPYTLLMIIRAACHGHCVPDYWYETSFWLLWANSAVNPVLYPLCHHSFR
RAFTKLLCPQKLKIQPHSSLEHCWK
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| BDBM50126888 |
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| n/a |
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| Name | BDBM50126888 |
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| Synonyms: | 1-[4-(4-Piperidin-1-ylmethyl-benzyloxy)-benzyl]-piperazine; compound with oxalic acid | CHEMBL193978 | CHEMBL416053 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H34N2O |
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| Mol. Mass. | 378.5503 |
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| SMILES | C(Oc1ccc(CN2CCCCC2)cc1)c1ccc(CN2CCCCC2)cc1 |
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| Structure | 
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