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TargetHistamine receptor (H3)
LigandBDBM50126888
Substrate/Competitorn/a
Meas. Tech.ChEMBL_304030
Ki 2.82±n/a nM
Citation Dvorak CAApodaca RBarbier AJBerridge CWWilson SJBoggs JDXiao WLovenberg TWCarruthers NI 4-phenoxypiperidines: potent, conformationally restricted, non-imidazole histamine H3 antagonists. J Med Chem 48:2229-38 (2005) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Histamine receptor (H3)
Name:Histamine receptor (H3 and H4)
Synonyms:G-protein coupled receptor 97 | HH3R | HISTAMINE H3 | HRH3 | Histamine H3 Receptor | Histamine H3 receptor (H3) | Histamine H3L | Histamine receptor (H3 and H4)
Type:G Protein-Coupled Receptor (GPCR)
Mol. Mass.:48691.47
Organism:Homo sapiens (Human)
Description:Binding assays were using CHO cells stably expressing hH3R receptors.
Residue:445
Sequence:
MERAPPDGPLNASGALAGEAAAAGGARGFSAAWTAVLAALMALLIVATVLGNALVMLAFV
ADSSLRTQNNFFLLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCTS
SAFNIVLISYDRFLSVTRAVSYRAQQGDTRRAVRKMLLVWVLAFLLYGPAILSWEYLSGG
SSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGAREAA
GPEPPPEAQPSPPPPPGCWGCWQKGHGEAMPLHRYGVGEAAVGAEAGEATLGGGGGGGSV
ASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSFTQRFRLSRDRKVAKSL
AVIVSIFGLCWAPYTLLMIIRAACHGHCVPDYWYETSFWLLWANSAVNPVLYPLCHHSFR
RAFTKLLCPQKLKIQPHSSLEHCWK
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BDBM50126888
n/a
NameBDBM50126888
Synonyms:1-[4-(4-Piperidin-1-ylmethyl-benzyloxy)-benzyl]-piperazine; compound with oxalic acid | CHEMBL193978 | CHEMBL416053
TypeSmall organic molecule
Emp. Form.C25H34N2O
Mol. Mass.378.5503
SMILESC(Oc1ccc(CN2CCCCC2)cc1)c1ccc(CN2CCCCC2)cc1
Structure
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