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Target5-hydroxytryptamine receptor 1D
LigandBDBM50410425
Substrate/Competitorn/a
Meas. Tech.ChEMBL_321089 (CHEMBL883692)
Ki 7.94±n/a nM
Citation Heightman, TDGaster, LMPardoe, SLPilleux, JPHadley, MSMiddlemiss, DNPrice, GWRoberts, CScott, CMWatson, JMGordon, LJHolland, VAPowles, JRiley, GJStean, TOTrail, BKUpton, NAustin, NEAyrton, ADColeman, TCutler, L 8-Piperazinyl-2,3-dihydropyrrolo[3,2-g]isoquinolines: potent, selective, orally bioavailable 5-HT1 receptor ligands. Bioorg Med Chem Lett15:4370-4 (2005) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
5-hydroxytryptamine receptor 1D
Name:5-hydroxytryptamine receptor 1D
Synonyms:5-HT-1D | 5-HT-1D-alpha | 5-HT1D | 5-hydroxytryptamine receptor 1D (5-HT1D) | 5HT1D_HUMAN | HTR1D | HTR1DA | HTRL | Serotonin (5-HT) receptor | Serotonin Receptor 1D
Type:G Protein-Coupled Receptor (GPCR)
Mol. Mass.:41920.63
Organism:Homo sapiens (Human)
Description:Receptor binding assays were performed using human clone stably expressed in CHO cells.
Residue:377
Sequence:
MSPLNQSAEGLPQEASNRSLNATETSEAWDPRTLQALKISLAVVLSVITLATVLSNAFVL
TTILLTRKLHTPANYLIGSLATTDLLVSILVMPISIAYTITHTWNFGQILCDIWLSSDIT
CCTASILHLCVIALDRYWAITDALEYSKRRTAGHAATMIAIVWAISICISIPPLFWRQAK
AQEEMSDCLVNTSQISYTIYSTCGAFYIPSVLLIILYGRIYRAARNRILNPPSLYGKRFT
TAHLITGSAGSSLCSLNSSLHEGHSHSAGSPLFFNHVKIKLADSALERKRISAARERKAT
KILGIILGAFIICWLPFFVVSLVLPICRDSCWIHPALFDFFTWLGYLNSLINPIIYTVFN
EEFRQAFQKIVPFRKAS
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50410425
n/a
NameBDBM50410425
Synonyms:CHEMBL198488
TypeSmall organic molecule
Emp. Form.C31H33N7O
Mol. Mass.519.64
SMILESCCc1c(cnn1-c1ccc(cc1)C#N)C(=O)N1CCc2cc3ccnc(N4CCN(CC4)C(C)C)c3cc12
Structure
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