Ki Summary

Reaction Details

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Target

Gastrin/cholecystokinin type B receptor

Ligand

BDBM50410564

Substrate/Competitor

n/a

Meas. Tech.

ChEMBL_321686 (CHEMBL872181)

IC50

11±n/a nM

Citation

Buck, IM; Black, JW; Cooke, T; Dunstone, DJ; Gaffen, JD; Griffin, EP; Harper, EA; Hull, RA; Kalindjian, SB; Lilley, EJ; Linney, ID; Low, CM; McDonald, IM; Pether, MJ; Roberts, SP; Shankley, NP; Shaxted, ME; Steel, KI; Sykes, DA; Tozer, MJ; Watt, GF; Walker, MK; Wright, L; Wright, PT Optimization of the in vitro and in vivo properties of a novel series of 2,4,5-trisubstituted imidazoles as potent cholecystokinin-2 (CCK2) antagonists. J Med Chem48:6803-12 (2005) [PubMed] Article

More Info.:

Get all data from this article, Assay Method

Gastrin/cholecystokinin type B receptor

Name:

Gastrin/cholecystokinin type B receptor

Synonyms:

CCKBR | Cholecystokinin B | Cholecystokinin B receptor | GASR_CANLF | Gastrin/cholecystokinin type B receptor

Type:

Enzyme Catalytic Domain

Mol. Mass.:

48544.19

Organism:

Dog

Description:

Cholecystokinin B 0 Dog::P30552

Residue:

453

Sequence:

MELLKLNRSAQGSGAGPGASLCRAGGALLNSSGAGNLSCEPPRLRGAGTRELELAIRVTL
YAVIFLMSVGGNVLIIVVLGLSRRLRTVTNAFLLSLAVSDLLLAVACMPFTLLPNLMGTF
IFGTVVCKAVSYLMGVSVSVSTLSLVAIALERYSAICRPLQARVWQTRSHAARVIIATWM
LSGLLMVPYPVYTAVQPAGGARALQCVHRWPSARVRQTWSVLLLLLLFFVPGVVMAVAYG
LISRELYLGLRFDEDSDSESRVRSQGGLRGGAGPGPAPPNGSCRPEGGLAGEDGDGCYVQ
LPRSRQTLELSALTAPTPGPGGGPRPYQAKLLAKKRVVRMLLVIVVLFFLCWLPLYSANT
WRAFDSSGAHRALSGAPISFIHLLSYASACVNPLVYCFMHRRFRQACLETCARCCPRPPR
ARPRPLPDEDPPTPSIASLSRLSYTTISTLGPG

BDBM50410564

n/a

Name

BDBM50410564

Synonyms:

CHEMBL425574

Type

Small organic molecule

Emp. Form.

C31H41N3O3

Mol. Mass.

503.6755

SMILES

Cc1ccc(NC(=O)c2[nH]c(nc2CCC23CC4CC(CC(C4)C2)C3)C2(C)CCCCC2)cc1C(O)=O |TLB:22:17:24:21.23.20,22:21:24:17.16.18,18:19:23:17.16.22,THB:18:17:23:19.24.20,20:19:16:21.23.22,20:21:16:19.24.18|

Structure