| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Tryptase beta-2 |
|---|
| Ligand | BDBM50411008 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_370996 (CHEMBL868494) |
|---|
| Ki | 5.8±n/a nM |
|---|
| Citation |  Palmer, JT; Rydzewski, RM; Mendonca, RV; Sperandio, D; Spencer, JR; Hirschbein, BL; Lohman, J; Beltman, J; Nguyen, M; Liu, L Design and synthesis of selective keto-1,2,4-oxadiazole-based tryptase inhibitors. Bioorg Med Chem Lett16:3434-9 (2006) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Tryptase beta-2 |
|---|
| Name: | Tryptase beta-2 |
|---|
| Synonyms: | TPS2 | TPSB2 | TRYB2_HUMAN | Tryptase | Tryptase II | Tryptase beta-1 | Tryptase-2 |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 30518.79 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_210702 |
|---|
| Residue: | 275 |
|---|
| Sequence: | MLNLLLLALPVLASRAYAAPAPGQALQRVGIVGGQEAPRSKWPWQVSLRVHGPYWMHFCG
GSLIHPQWVLTAAHCVGPDVKDLAALRVQLREQHLYYQDQLLPVSRIIVHPQFYTAQIGA
DIALLELEEPVNVSSHVHTVTLPPASETFPPGMPCWVTGWGDVDNDERLPPPFPLKQVKV
PIMENHICDAKYHLGAYTGDDVRIVRDDMLCAGNTRRDSCQGDSGGPLVCKVNGTWLQAG
VVSWGEGCAQPNRPGIYTRVTYYLDWIHHYVPKKP
|
|
|
|---|
| BDBM50411008 |
|---|
| n/a |
|---|
| Name | BDBM50411008 |
|---|
| Synonyms: | CHEMBL535836 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C30H29Cl2FN4O4 |
|---|
| Mol. Mass. | 599.48 |
|---|
| SMILES | NCCCC[C@H](NC(=O)c1cccc(F)c1)C(=O)c1noc(Cc2ccc(OCCc3ccc(Cl)c(Cl)c3)cc2)n1 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
