Reaction Details |
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Target | 7-dehydrocholesterol reductase |
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Ligand | BDBM22984 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_430046 (CHEMBL644842) |
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IC50 | 10000±n/a nM |
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Citation | Burke, PJ; Kalet, BT; Koch, TH Antiestrogen binding site and estrogen receptor mediate uptake and distribution of 4-hydroxytamoxifen-targeted doxorubicin-formaldehyde conjugate in breast cancer cells. J Med Chem47:6509-18 (2004) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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7-dehydrocholesterol reductase |
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Name: | 7-dehydrocholesterol reductase |
Synonyms: | 7-DHC reductase | 7-dehydrocholesterol reductase | Anti-estrogen binding site (AEBS) | D7SR | DHCR7 | DHCR7_HUMAN | Putative sterol reductase SR-2 | Sterol Delta(7)-reductase |
Type: | PROTEIN |
Mol. Mass.: | 54508.42 |
Organism: | Homo sapiens (Human) |
Description: | ChEMBL_864350 |
Residue: | 475 |
Sequence: | MAAKSQPNIPKAKSLDGVTNDRTASQGQWGRAWEVDWFSLASVIFLLLFAPFIVYYFIMA
CDQYSCALTGPVVDIVTGHARLSDIWAKTPPITRKAAQLYTLWVTFQVLLYTSLPDFCHK
FLPGYVGGIQEGAVTPAGVVNKYQINGLQAWLLTHLLWFANAHLLSWFSPTIIFDNWIPL
LWCANILGYAVSTFAMVKGYFFPTSARDCKFTGNFFYNYMMGIEFNPRIGKWFDFKLFFN
GRPGIVAWTLINLSFAAKQRELHSHVTNAMVLVNVLQAIYVIDFFWNETWYLKTIDICHD
HFGWYLGWGDCVWLPYLYTLQGLYLVYHPVQLSTPHAVGVLLLGLVGYYIFRVANHQKDL
FRRTDGRCLIWGRKPKVIECSYTSADGQRHHSKLLVSGFWGVARHFNYVGDLMGSLAYCL
ACGGGHLLPYFYIIYMAILLTHRCLRDEHRCASKYGRDWERYTAAVPYRLLPGIF
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BDBM22984 |
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n/a |
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Name | BDBM22984 |
Synonyms: | (8S,10S)-10-{[(2R,4S,5S,6S)-4-amino-5-hydroxy-6-methyloxan-2-yl]oxy}-6,8,11-trihydroxy-8-(2-hydroxyacetyl)-1-methoxy-5,7,8,9,10,12-hexahydrotetracene-5,12-dione | Adriamycin | Adriblastina | CHEMBL53463 | Doxil | Doxorubicin |
Type | Antibiotic |
Emp. Form. | C27H29NO11 |
Mol. Mass. | 543.5193 |
SMILES | COc1cccc2C(=O)c3c(O)c4C[C@](O)(C[C@H](O[C@H]5C[C@H](N)[C@H](O)[C@H](C)O5)c4c(O)c3C(=O)c12)C(=O)CO |r| |
Structure |
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