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TargetGastrin/cholecystokinin type B receptor
LigandBDBM50411337
Substrate/Competitorn/a
Meas. Tech.ChEMBL_439007 (CHEMBL889353)
Ki 26±n/a nM
Citation McDonald, IMBlack, JWBuck, IMDunstone, DJGriffin, EPHarper, EAHull, RAKalindjian, SBLilley, EJLinney, IDPether, MJRoberts, SPShaxted, MESpencer, JSteel, KISykes, DAWalker, MKWatt, GFWright, LWright, PTXun, W Optimization of 1,3,4-benzotriazepine-based CCK(2) antagonists to obtain potent, orally active inhibitors of gastrin-mediated gastric acid secretion. J Med Chem50:3101-12 (2007) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Gastrin/cholecystokinin type B receptor
Name:Gastrin/cholecystokinin type B receptor
Synonyms:CCKBR | Cholecystokinin B | Cholecystokinin B receptor | GASR_CANLF | Gastrin/cholecystokinin type B receptor
Type:Enzyme Catalytic Domain
Mol. Mass.:48544.19
Organism:Dog
Description:Cholecystokinin B 0 Dog::P30552
Residue:453
Sequence:
MELLKLNRSAQGSGAGPGASLCRAGGALLNSSGAGNLSCEPPRLRGAGTRELELAIRVTL
YAVIFLMSVGGNVLIIVVLGLSRRLRTVTNAFLLSLAVSDLLLAVACMPFTLLPNLMGTF
IFGTVVCKAVSYLMGVSVSVSTLSLVAIALERYSAICRPLQARVWQTRSHAARVIIATWM
LSGLLMVPYPVYTAVQPAGGARALQCVHRWPSARVRQTWSVLLLLLLFFVPGVVMAVAYG
LISRELYLGLRFDEDSDSESRVRSQGGLRGGAGPGPAPPNGSCRPEGGLAGEDGDGCYVQ
LPRSRQTLELSALTAPTPGPGGGPRPYQAKLLAKKRVVRMLLVIVVLFFLCWLPLYSANT
WRAFDSSGAHRALSGAPISFIHLLSYASACVNPLVYCFMHRRFRQACLETCARCCPRPPR
ARPRPLPDEDPPTPSIASLSRLSYTTISTLGPG
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50411337
n/a
NameBDBM50411337
Synonyms:CHEMBL390276
TypeSmall organic molecule
Emp. Form.C32H32N4O5
Mol. Mass.552.6203
SMILESCc1ccccc1C(=O)CN1c2ccccc2C(=NN(CC(=O)Nc2cccc(c2)C(O)=O)C1=O)C1CCCCC1 |c:19|
Structure
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