| Reaction Details |
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 | Report a problem with these data |
| Target | Cholecystokinin receptor |
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| Ligand | BDBM50002875 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_439002 |
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| Ki | 0.25±n/a nM |
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| Citation |  McDonald IM; Black JW; Buck IM; Dunstone DJ; Griffin EP; Harper EA; Hull RA; Kalindjian SB; Lilley EJ; Linney ID; Pether MJ; Roberts SP; Shaxted ME; Spencer J; Steel KI; Sykes DA; Walker MK; Watt GF; Wright L; Wright PT; Xun W Optimization of 1,3,4-benzotriazepine-based CCK(2) antagonists to obtain potent, orally active inhibitors of gastrin-mediated gastric acid secretion. J Med Chem 50:3101-12 (2007) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Cholecystokinin receptor |
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| Name: | Cholecystokinin receptor |
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| Synonyms: | CCK-2 receptor | CCK-B receptor | CCK-BR | CCKBR | Cholecystokinin A | Cholecystokinin-2 Receptor | Gastrin/cholecystokinin type B receptor |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 48445.79 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Stable expression of human CCK-2 receptors in HEK 293 cells. |
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| Residue: | 447 |
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| Sequence: | MELLKLNRSVQGTGPGPGASLCRPGAPLLNSSSVGNLSCEPPRIRGAGTRELELAIRITL
YAVIFLMSVGGNMLIIVVLGLSRRLRTVTNAFLLSLAVSDLLLAVACMPFTLLPNLMGTF
IFGTVICKAVSYLMGVSVSVSTLSLVAIALERYSAICRPLQARVWQTRSHAARVIVATWL
LSGLLMVPYPVYTVVQPVGPRVLQCVHRWPSARVRQTWSVLLLLLLFFIPGVVMAVAYGL
ISRELYLGLRFDGDSDSDSQSRVRNQGGLPGAVHQNGRCRPETGAVGEDSDGCYVQLPRS
RPALELTALTAPGPGSGSRPTQAKLLAKKRVVRMLLVIVVLFFLCWLPVYSANTWRAFDG
PGAHRALSGAPISFIHLLSYASACVNPLVYCFMHRRFRQACLETCARCCPRPPRARPRAL
PDEDPPTPSIASLSRLSYTTISTLGPG
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| BDBM50002875 |
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| n/a |
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| Name | BDBM50002875 |
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| Synonyms: | CHEMBL388144 |
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| Type | Small organic molecule |
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| Emp. Form. | C33H36N4O6 |
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| Mol. Mass. | 584.6621 |
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| SMILES | CC(C)(C)C(=O)CN1c2ccccc2C(=NN(CC(=O)Nc2cccc(c2)-c2ccc(o2)C(O)=O)C1=O)C1CCCCC1 |c:15| |
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| Structure | 
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