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TargetParathyroid hormone receptor
LigandBDBM50002926
Substrate/Competitorn/a
Meas. Tech.ChEMBL_446293
Ki 0.91±n/a nM
Citation McDonald IMAustin CBuck IMDunstone DJGaffen JGriffin EHarper EAHull RAKalindjian SBLinney IDLow CMPatel DPether MJRaynor MRoberts SPShaxted MESpencer JSteel KISykes DAWright PTXun W Discovery and characterization of novel, potent, non-peptide parathyroid hormone-1 receptor antagonists. J Med Chem 50:4789-92 (2007) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Parathyroid hormone receptor
Name:Parathyroid hormone receptor
Synonyms:PTH/PTHr receptor | PTH/PTHrP type I receptor | PTH1 receptor | Parathyroid hormone 1 receptor
Type:Enzyme Catalytic Domain
Mol. Mass.:66370.95
Organism:Homo sapiens (Human)
Description:PARATHYROID HT1 0 HUMAN::Q03431
Residue:593
Sequence:
MGTARIAPGLALLLCCPVLSSAYALVDADDVMTKEEQIFLLHRAQAQCEKRLKEVLQRPA
SIMESDKGWTSASTSGKPRKDKASGKLYPESEEDKEAPTGSRYRGRPCLPEWDHILCWPL
GAPGEVVAVPCPDYIYDFNHKGHAYRRCDRNGSWELVPGHNRTWANYSECVKFLTNETRE
REVFDRLGMIYTVGYSVSLASLTVAVLILAYFRRLHCTRNYIHMHLFLSFMLRAVSIFVK
DAVLYSGATLDEAERLTEEELRAIAQAPPPPATAAAGYAGCRVAVTFFLYFLATNYYWIL
VEGLYLHSLIFMAFFSEKKYLWGFTVFGWGLPAVFVAVWVSVRATLANTGCWDLSSGNKK
WIIQVPILASIVLNFILFINIVRVLATKLRETNAGRCDTRQQYRKLLKSTLVLMPLFGVH
YIVFMATPYTEVSGTLWQVQMHYEMLFNSFQGFFVAIIYCFCNGEVQAEIKKSWSRWTLA
LDFKRKARSGSSSYSYGPMVSHTSVTNVGPRVGLGLPLSPRLLPTATTNGHPQLPGHAKP
GTPALETLETTPPAMAAPKDDGFLNGSCSGLDEEASGPERPPALLQEEWETVM
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  Blast E-value cutoff:
BDBM50002926
n/a
NameBDBM50002926
Synonyms:CHEMBL244325
TypeSmall organic molecule
Emp. Form.C37H42N6O
Mol. Mass.586.769
SMILESCc1ccc2c(c1)N(c1ccc(NCCc3ncc[nH]3)cc1)C(=O)N(N=C2C1CCCCC1)C1CCc2ccccc2CC1 |c:28|
Structure
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