Reaction Details |
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Target | Parathyroid hormone/parathyroid hormone-related peptide receptor |
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Ligand | BDBM50002919 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_446293 (CHEMBL895396) |
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Ki | 676±n/a nM |
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Citation | McDonald, IM; Austin, C; Buck, IM; Dunstone, DJ; Gaffen, J; Griffin, E; Harper, EA; Hull, RA; Kalindjian, SB; Linney, ID; Low, CM; Patel, D; Pether, MJ; Raynor, M; Roberts, SP; Shaxted, ME; Spencer, J; Steel, KI; Sykes, DA; Wright, PT; Xun, W Discovery and characterization of novel, potent, non-peptide parathyroid hormone-1 receptor antagonists. J Med Chem50:4789-92 (2007) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Parathyroid hormone/parathyroid hormone-related peptide receptor |
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Name: | Parathyroid hormone/parathyroid hormone-related peptide receptor |
Synonyms: | PTH/PTHr receptor | PTH/PTHrP type I receptor | PTH1 receptor | PTH1R | PTH1R_HUMAN | PTHR | PTHR1 | Parathyroid hormone 1 receptor | Parathyroid hormone receptor |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 66370.95 |
Organism: | Homo sapiens (Human) |
Description: | PARATHYROID HT1 0 HUMAN::Q03431 |
Residue: | 593 |
Sequence: | MGTARIAPGLALLLCCPVLSSAYALVDADDVMTKEEQIFLLHRAQAQCEKRLKEVLQRPA
SIMESDKGWTSASTSGKPRKDKASGKLYPESEEDKEAPTGSRYRGRPCLPEWDHILCWPL
GAPGEVVAVPCPDYIYDFNHKGHAYRRCDRNGSWELVPGHNRTWANYSECVKFLTNETRE
REVFDRLGMIYTVGYSVSLASLTVAVLILAYFRRLHCTRNYIHMHLFLSFMLRAVSIFVK
DAVLYSGATLDEAERLTEEELRAIAQAPPPPATAAAGYAGCRVAVTFFLYFLATNYYWIL
VEGLYLHSLIFMAFFSEKKYLWGFTVFGWGLPAVFVAVWVSVRATLANTGCWDLSSGNKK
WIIQVPILASIVLNFILFINIVRVLATKLRETNAGRCDTRQQYRKLLKSTLVLMPLFGVH
YIVFMATPYTEVSGTLWQVQMHYEMLFNSFQGFFVAIIYCFCNGEVQAEIKKSWSRWTLA
LDFKRKARSGSSSYSYGPMVSHTSVTNVGPRVGLGLPLSPRLLPTATTNGHPQLPGHAKP
GTPALETLETTPPAMAAPKDDGFLNGSCSGLDEEASGPERPPALLQEEWETVM
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BDBM50002919 |
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n/a |
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Name | BDBM50002919 |
Synonyms: | CHEMBL242589 |
Type | Small organic molecule |
Emp. Form. | C29H31N5O2 |
Mol. Mass. | 481.5887 |
SMILES | NCC(=O)Nc1ccc(cc1)N1c2ccccc2C(=NN(Cc2ccccc2)C1=O)C1CCCCC1 |c:20| |
Structure |
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