Reaction Details |
| Report a problem with these data |
Target | Histamine H1 receptor |
---|
Ligand | BDBM50411713 |
---|
Substrate/Competitor | n/a |
---|
Meas. Tech. | ChEMBL_465005 (CHEMBL948182) |
---|
Ki | >3162.28±n/a nM |
---|
Citation | Micheli, F; Bonanomi, G; Braggio, S; Capelli, AM; Celestini, P; Damiani, F; Di Fabio, R; Donati, D; Gagliardi, S; Gentile, G; Hamprecht, D; Petrone, M; Radaelli, S; Tedesco, G; Terreni, S; Worby, A; Heidbreder, C New fused benzazepine as selective D3 receptor antagonists. Synthesis and biological evaluation. Part one: [h]-fused tricyclic systems. Bioorg Med Chem Lett18:901-7 (2008) [PubMed] Article |
---|
More Info.: | Get all data from this article, Assay Method |
---|
|
Histamine H1 receptor |
---|
Name: | Histamine H1 receptor |
Synonyms: | H1R | HH1R | HISTAMINE H1 | HRH1 | HRH1_HUMAN |
Type: | G Protein-Coupled Receptor (GPCR) |
Mol. Mass.: | 55808.72 |
Organism: | Homo sapiens (Human) |
Description: | Cell pellets from SK-N-MC cells transfected with human H1 receptor were used in binding assay. |
Residue: | 487 |
Sequence: | MSLPNSSCLLEDKMCEGNKTTMASPQLMPLVVVLSTICLVTVGLNLLVLYAVRSERKLHT
VGNLYIVSLSVADLIVGAVVMPMNILYLLMSKWSLGRPLCLFWLSMDYVASTASIFSVFI
LCIDRYRSVQQPLRYLKYRTKTRASATILGAWFLSFLWVIPILGWNHFMQQTSVRREDKC
ETDFYDVTWFKVMTAIINFYLPTLLMLWFYAKIYKAVRQHCQHRELINRSLPSFSEIKLR
PENPKGDAKKPGKESPWEVLKRKPKDAGGGSVLKSPSQTPKEMKSPVVFSQEDDREVDKL
YCFPLDIVHMQAAAEGSSRDYVAVNRSHGQLKTDEQGLNTHGASEISEDQMLGDSQSFSR
TDSDTTTETAPGKGKLRSGSNTGLDYIKFTWKRLRSHSRQYVSGLHMNRERKAAKQLGFI
MAAFILCWIPYFIFFMVIAFCKNCCNEHLHMFTIWLGYINSTLNPLIYPLCNENFKKTFK
RILHIRS
|
|
|
BDBM50411713 |
---|
n/a |
---|
Name | BDBM50411713 |
Synonyms: | CHEMBL255620 |
Type | Small organic molecule |
Emp. Form. | C29H33N7OS |
Mol. Mass. | 527.684 |
SMILES | CN(C)c1nc2cc3CCN(CCCSc4nnc(-c5cccc6nc(C)ccc56)n4C)CCc3cc2o1 |
Structure |
|