| Reaction Details |
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 | Report a problem with these data |
| Target | Heparanase |
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| Ligand | BDBM50147546 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_531583 (CHEMBL990587) |
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| IC50 | 200±n/a nM |
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| Citation |  Jalali-Heravi, M; Asadollahi-Baboli, M; Shahbazikhah, P QSAR study of heparanase inhibitors activity using artificial neural networks and Levenberg-Marquardt algorithm. Eur J Med Chem43:548-56 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Heparanase |
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| Name: | Heparanase |
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| Synonyms: | Endo-glucoronidase | HEP | HPA | HPA1 | HPR1 | HPSE | HPSE1 | HPSE_HUMAN | HSE1 | Heparanase 50 kDa subunit | Heparanase 8 kDa subunit | Heparanase-1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 61167.67 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_327900 |
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| Residue: | 543 |
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| Sequence: | MLLRSKPALPPPLMLLLLGPLGPLSPGALPRPAQAQDVVDLDFFTQEPLHLVSPSFLSVT
IDANLATDPRFLILLGSPKLRTLARGLSPAYLRFGGTKTDFLIFDPKKESTFEERSYWQS
QVNQDICKYGSIPPDVEEKLRLEWPYQEQLLLREHYQKKFKNSTYSRSSVDVLYTFANCS
GLDLIFGLNALLRTADLQWNSSNAQLLLDYCSSKGYNISWELGNEPNSFLKKADIFINGS
QLGEDFIQLHKLLRKSTFKNAKLYGPDVGQPRRKTAKMLKSFLKAGGEVIDSVTWHHYYL
NGRTATKEDFLNPDVLDIFISSVQKVFQVVESTRPGKKVWLGETSSAYGGGAPLLSDTFA
AGFMWLDKLGLSARMGIEVVMRQVFFGAGNYHLVDENFDPLPDYWLSLLFKKLVGTKVLM
ASVQGSKRRKLRVYLHCTNTDNPRYKEGDLTLYAINLHNVTKYLRLPYPFSNKQVDKYLL
RPLGPHGLLSKSVQLNGLTLKMVDDQTLPPLMEKPLRPGSSLGLPAFSYSFFVIRNAKVA
ACI
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| BDBM50147546 |
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| n/a |
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| Name | BDBM50147546 |
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| Synonyms: | 2-(3-(5-(benzo[d][1,3]dioxol-5-yl)benzo[d]oxazol-2-yl)-4-methoxyphenyl)-1,3-dioxoisoindoline-5-carboxylic acid | 2-[3-(5-Benzo[1,3]dioxol-5-yl-benzooxazol-2-yl)-4-methoxy-phenyl]-1,3-dioxo-indan-5-carboxylic acid | CHEMBL326904 |
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| Type | Small organic molecule |
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| Emp. Form. | C30H18N2O8 |
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| Mol. Mass. | 534.4725 |
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| SMILES | COc1ccc(cc1-c1nc2cc(ccc2o1)-c1ccc2OCOc2c1)N1C(=O)c2ccc(cc2C1=O)C(O)=O |
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| Structure | 
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