| Reaction Details |
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 | Report a problem with these data |
| Target | Beta-2 adrenergic receptor |
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| Ligand | BDBM50412132 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_556328 (CHEMBL954063) |
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| Ki | 501±n/a nM |
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| Citation |  Ward, SE; Eddershaw, PJ; Scott, CM; Gordon, LJ; Lovell, PJ; Moore, SH; Smith, PW; Starr, KR; Thewlis, KM; Watson, JM Discovery of potent, orally bioavailable, selective 5-HT1A/B/D receptor antagonists. J Med Chem51:2887-90 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Beta-2 adrenergic receptor |
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| Name: | Beta-2 adrenergic receptor |
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| Synonyms: | ADRB2 | ADRB2R | ADRB2_HUMAN | B2AR | Beta-2 adrenoceptor | Beta-2 adrenoreceptor |
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| Type: | n/a |
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| Mol. Mass.: | 46461.69 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P07550 |
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| Residue: | 413 |
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| Sequence: | MGQPGNGSAFLLAPNGSHAPDHDVTQERDEVWVVGMGIVMSLIVLAIVFGNVLVITAIAK
FERLQTVTNYFITSLACADLVMGLAVVPFGAAHILMKMWTFGNFWCEFWTSIDVLCVTAS
IETLCVIAVDRYFAITSPFKYQSLLTKNKARVIILMVWIVSGLTSFLPIQMHWYRATHQE
AINCYANETCCDFFTNQAYAIASSIVSFYVPLVIMVFVYSRVFQEAKRQLQKIDKSEGRF
HVQNLSQVEQDGRTGHGLRRSSKFCLKEHKALKTLGIIMGTFTLCWLPFFIVNIVHVIQD
NLIRKEVYILLNWIGYVNSGFNPLIYCRSPDFRIAFQELLCLRRSSLKAYGNGYSSNGNT
GEQSGYHVEQEKENKLLCEDLPGTEDFVGHQGTVPSDNIDSQGRNCSTNDSLL
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| BDBM50412132 |
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| n/a |
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| Name | BDBM50412132 |
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| Synonyms: | CHEMBL497963 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H31N3O3S |
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| Mol. Mass. | 453.597 |
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| SMILES | Cc1ccc2c(OCCN3CCC(Cc4cccc(NS(C)(=O)=O)c4)CC3)cccc2n1 |
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| Structure | 
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