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Target5-hydroxytryptamine receptor 1D
LigandBDBM50412119
Substrate/Competitorn/a
Meas. Tech.ChEMBL_556307 (CHEMBL954042)
Ki 1±n/a nM
Citation Ward, SEEddershaw, PJScott, CMGordon, LJLovell, PJMoore, SHSmith, PWStarr, KRThewlis, KMWatson, JM Discovery of potent, orally bioavailable, selective 5-HT1A/B/D receptor antagonists. J Med Chem51:2887-90 (2008) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
5-hydroxytryptamine receptor 1D
Name:5-hydroxytryptamine receptor 1D
Synonyms:5-HT-1D | 5-HT-1D-alpha | 5-HT1D | 5-hydroxytryptamine receptor 1D (5-HT1D) | 5HT1D_HUMAN | HTR1D | HTR1DA | HTRL | Serotonin (5-HT) receptor | Serotonin Receptor 1D
Type:G Protein-Coupled Receptor (GPCR)
Mol. Mass.:41920.63
Organism:Homo sapiens (Human)
Description:Receptor binding assays were performed using human clone stably expressed in CHO cells.
Residue:377
Sequence:
MSPLNQSAEGLPQEASNRSLNATETSEAWDPRTLQALKISLAVVLSVITLATVLSNAFVL
TTILLTRKLHTPANYLIGSLATTDLLVSILVMPISIAYTITHTWNFGQILCDIWLSSDIT
CCTASILHLCVIALDRYWAITDALEYSKRRTAGHAATMIAIVWAISICISIPPLFWRQAK
AQEEMSDCLVNTSQISYTIYSTCGAFYIPSVLLIILYGRIYRAARNRILNPPSLYGKRFT
TAHLITGSAGSSLCSLNSSLHEGHSHSAGSPLFFNHVKIKLADSALERKRISAARERKAT
KILGIILGAFIICWLPFFVVSLVLPICRDSCWIHPALFDFFTWLGYLNSLINPIIYTVFN
EEFRQAFQKIVPFRKAS
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  Blast E-value cutoff:
BDBM50412119
n/a
NameBDBM50412119
Synonyms:CHEMBL494631
TypeSmall organic molecule
Emp. Form.C23H27N3O
Mol. Mass.361.48
SMILESCc1ccc2c(OCCN3CCN(Cc4ccccc4)CC3)cccc2n1
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: