| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Alpha-2B adrenergic receptor |
|---|
| Ligand | BDBM50019492 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_487921 (CHEMBL1016575) |
|---|
| Ki | 1.6±n/a nM |
|---|
| Citation |  Gentili, F; Cardinaletti, C; Vesprini, C; Carrieri, A; Ghelfi, F; Farande, A; Giannella, M; Piergentili, A; Quaglia, W; Laurila, JM; Huhtinen, A; Scheinin, M; Pigini, M Alpha2-adrenoreceptors profile modulation. 4. From antagonist to agonist behavior. J Med Chem51:4289-99 (2008) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Alpha-2B adrenergic receptor |
|---|
| Name: | Alpha-2B adrenergic receptor |
|---|
| Synonyms: | ADA2B_HUMAN | ADRA2B | ADRA2L1 | ADRA2RL1 | Adrenergic alpha2B | Adrenergic receptor | Adrenergic receptor alpha | Adrenergic, alpha-2B-, receptor [Homo sapiens] | Alpha-2 adrenergic receptor subtype C2 | Alpha-2B adrenoceptor | Alpha-2B adrenoreceptor | Alpha-2BAR |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 49964.20 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P18089 |
|---|
| Residue: | 450 |
|---|
| Sequence: | MDHQDPYSVQATAAIAAAITFLILFTIFGNALVILAVLTSRSLRAPQNLFLVSLAAADIL
VATLIIPFSLANELLGYWYFRRTWCEVYLALDVLFCTSSIVHLCAISLDRYWAVSRALEY
NSKRTPRRIKCIILTVWLIAAVISLPPLIYKGDQGPQPRGRPQCKLNQEAWYILASSIGS
FFAPCLIMILVYLRIYLIAKRSNRRGPRAKGGPGQGESKQPRPDHGGALASAKLPALASV
ASAREVNGHSKSTGEKEEGETPEDTGTRALPPSWAALPNSGQGQKEGVCGASPEDEAEEE
EEEEEEEEECEPQAVPVSPASACSPPLQQPQGSRVLATLRGQVLLGRGVGAIGGQWWRRR
AQLTREKRFTFVLAVVIGVFVLCWFPFFFSYSLGAICPKHCKVPHGLFQFFFWIGYCNSS
LNPVIYTIFNQDFRRAFRRILCRPWTQTAW
|
|
|
|---|
| BDBM50019492 |
|---|
| n/a |
|---|
| Name | BDBM50019492 |
|---|
| Synonyms: | (+)2-(2-Methoxy-2,3-dihydro-benzo[1,4]dioxin-2-yl)-4,5-dihydro-1H-imidazole | (-)2-(2-Methoxy-2,3-dihydro-benzo[1,4]dioxin-2-yl)-4,5-dihydro-1H-imidazole | 2-(2,3-dihydro-2-methoxy-1,4-benzodioxin-2-yl)-4,5-dihydro-1H-imidazole | 2-(2-Methoxy-2,3-dihydro-benzo[1,4]dioxin-2-yl)-4,5-dihydro-1H-imidazole | 2-(2-methoxy-2,3-dihydrobenzo[b][1,4]dioxin-2-yl)-4,5-dihydro-1H-imidazole | 2-ethoxy-idazoxan | CHEMBL10332 | RX-821002 | RX821002 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C12H14N2O3 |
|---|
| Mol. Mass. | 234.2512 |
|---|
| SMILES | COC1(COc2ccccc2O1)C1=NCCN1 |t:14| |
|---|
| Structure | 
|
|---|
Search and Browse
