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TargetAlpha-2C adrenergic receptor
LigandBDBM50019848
Substrate/Competitorn/a
Meas. Tech.ChEMBL_487925 (CHEMBL1016579)
Ki 18±n/a nM
Citation Gentili, F; Cardinaletti, C; Vesprini, C; Carrieri, A; Ghelfi, F; Farande, A; Giannella, M; Piergentili, A; Quaglia, W; Laurila, JM; Huhtinen, A; Scheinin, M; Pigini, M Alpha2-adrenoreceptors profile modulation. 4. From antagonist to agonist behavior. J Med Chem51:4289-99 (2008) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Alpha-2C adrenergic receptor
Name:Alpha-2C adrenergic receptor
Synonyms:ADA2C_HUMAN | ADRA2C | ADRA2L2 | ADRA2RL2 | Adrenergic alpha2C | Adrenergic receptor | Adrenergic receptor alpha | Adrenergic, alpha-2C-, receptor | Alpha-2 adrenergic receptor subtype C4 | Alpha-2C adrenoceptor | Alpha-2C adrenoreceptor | adrenergic, alpha-2C-, receptor [Homo sapiens]
Type:Enzyme
Mol. Mass.:49552.32
Organism:Homo sapiens (Human)
Description:P18825
Residue:462
Sequence:
MASPALAAALAVAAAAGPNASGAGERGSGGVANASGASWGPPRGQYSAGAVAGLAAVVGF
LIVFTVVGNVLVVIAVLTSRALRAPQNLFLVSLASADILVATLVMPFSLANELMAYWYFG
QVWCGVYLALDVLFCTSSIVHLCAISLDRYWSVTQAVEYNLKRTPRRVKATIVAVWLISA
VISFPPLVSLYRQPDGAAYPQCGLNDETWYILSSCIGSFFAPCLIMGLVYARIYRVAKLR
TRTLSEKRAPVGPDGASPTTENGLGAAAGAGENGHCAPPPADVEPDESSAAAERRRRRGA
LRRGGRRRAGAEGGAGGADGQGAGPGAAESGALTASRSPGPGGRLSRASSRSVEFFLSRR
RRARSSVCRRKVAQAREKRFTFVLAVVMGVFVLCWFPFFFSYSLYGICREACQVPGPLFK
FFFWIGYCNSSLNPVIYTVFNQDFRRSFKHILFRRRRRGFRQ
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50019848
n/a
NameBDBM50019848
Synonyms:2-(2,3-dihydro-1,4-benzodioxin-2-yl)-4,5-dihydro-1H-imidazole | 4,5-dihydro-2-(2,3-dihydro-1,4-benzodioxin-2-yl)-1H-imidazole | CHEMBL10316 | Idazoxan | US8633208, Idazoxan
TypeSmall organic molecule
Emp. Form.C11H12N2O2
Mol. Mass.204.2252
SMILESC1CN=C(N1)C1COc2ccccc2O1 |c:2|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: