| Reaction Details |
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 | Report a problem with these data |
| Target | Calcium-activated potassium channel subunit alpha-1 |
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| Ligand | BDBM50412339 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_510400 (CHEMBL1000350) |
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| IC50 | 39.81±n/a nM |
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| Citation |  Calderone, V; Spogli, R; Martelli, A; Manfroni, G; Testai, L; Sabatini, S; Tabarrini, O; Cecchetti, V Novel 1,4-benzothiazine derivatives as large conductance Ca2+-activated potassium channel openers. J Med Chem51:5085-92 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Calcium-activated potassium channel subunit alpha-1 |
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| Name: | Calcium-activated potassium channel subunit alpha-1 |
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| Synonyms: | KCMA1_RAT | Kcnma | Kcnma1 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 134382.76 |
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| Organism: | Rattus norvegicus |
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| Description: | ChEMBL_510400 |
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| Residue: | 1209 |
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| Sequence: | MANGGGGGGGGSSGSSGGGGGGGGGETALRMSSNIHANHLSLDASSSSSSSSSSSSSSSS
SVHEPKMDALIIPVTMEVPCDSRGQRMWWAFLASSMVTFFGGLFIILLWRTLKYLWTVCC
HCGGKTKEAQKINNGSSQADGTLKPVDEKEEVVAAEVGWMTSVKDWAGVMISAQTLTGRV
LVVLVFALSIGALVIYFIDSSNPIESCQNFYKDFTLQIDMAFNVFFLLYFGLRFIAANDK
LWFWLEVNSVVDFFTVPPVFVSVYLNRSWLGLRFLRALRLIQFSEILQFLNILKTSNSIK
LVNLLSIFISTWLTAAGFIHLVENSGDPWENFQNNQALTYWECVYLLMVTMSTVGYGDVY
AKTTLGRLFMVFFILGGLAMFASYVPEIIELIGNRKKYGGSYSAVSGRKHIVVCGHITLE
SVSNFLKDFLHKDRDDVNVEIVFLHNISPNLELEALFKRHFTQVEFYQGSVLNPHDLARV
KIESADACLILANKYCADPDAEDASNIMRVISIKNYHPKIRIITQMLQYHNKAHLLNIPS
WNWKEGDDAICLAELKLGFIAQSCLAQGLSTMLANLFSMRSFIKIEEDTWQKYYLEGVSN
EMYTEYLSSAFVGLSFPTVCELCFVKLKLLMIAIEYKSANRESRSRKRILINPGNHLKIQ
EGTLGFFIASDAKEVKRAFFYCKACHDDVTDPKRIKKCGCRRLEDEQPPTLSPKKKQRNG
GMRNSPNTSPKLMRHDPLLIPGNDQIDNMDSNVKKYDSTGMFHWCAPKEIEKVILTRSEA
AMTVLSGHVVVCIFGDVSSALIGLRNLVMPLRASNFHYHELKHIVFVGSIEYLKREWETL
HNFPKVSILPGTPLSRADLRAVNINLCDMCVILSANQNNIDDTSLQDKECILASLNIKSM
QFDDSIGVLQANSQGFTPPGMDRSSPDNSPVHGMLRQPSITTGVNIPIITELAKPGKLPL
VSVNQEKNSGTHILMITELVNDTNVQFLDQDDDDDPDTELYLTQPFACGTAFAVSVLDSL
MSATYFNDNILTLIRTLVTGGATPELEALIAEENALRGGYSTPQTLANRDRCRVAQLALL
DGPFADLGDGGCYGDLFCKALKTYNMLCFGIYRLRDAHLSTPSQCTKRYVITNPPYEFEL
VPTDLIFCLMQFDHNAGQSRASLSHSSHSSQSSSKKSSSVHSIPSTANRPNRPKSRESRD
KQKKEMVYR
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| BDBM50412339 |
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| n/a |
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| Name | BDBM50412339 |
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| Synonyms: | CHEMBL496460 |
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| Type | Small organic molecule |
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| Emp. Form. | C16H11BrF3NO2S |
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| Mol. Mass. | 418.228 |
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| SMILES | COc1ccc(Br)cc1C1Sc2ccc(cc2NC1=O)C(F)(F)F |
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| Structure | 
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