| Reaction Details |
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 | Report a problem with these data |
| Target | 3-oxoacyl-[acyl-carrier-protein] synthase 3 |
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| Ligand | BDBM23572 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_510888 (CHEMBL997780) |
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| IC50 | 1600±n/a nM |
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| Citation |  Singh, S; Soni, LK; Gupta, MK; Prabhakar, YS; Kaskhedikar, SG QSAR studies on benzoylaminobenzoic acid derivatives as inhibitors of beta-ketoacyl-acyl carrier protein synthase III. Eur J Med Chem43:1071-80 (2008) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| 3-oxoacyl-[acyl-carrier-protein] synthase 3 |
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| Name: | 3-oxoacyl-[acyl-carrier-protein] synthase 3 |
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| Synonyms: | 3-oxoacyl-[acyl-carrier-protein] synthase 3 | 3-oxoacyl-[acyl-carrier-protein] synthase III | Beta-ketoacyl-ACP synthase III | FABH_ENTFA | KAS III | beta-Ketoacyl-ACP Synthase III (FabH) | fabH |
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| Type: | Acyltransferase; homodimer |
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| Mol. Mass.: | 35176.53 |
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| Organism: | Enterococcus faecalis |
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| Description: | The E. faecalis FabH was cloned, and protein was expressed in E. coli. |
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| Residue: | 321 |
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| Sequence: | MKNYARISCTSRYVPENCVTNHQLSEMMDTSDEWIHSRTGISERRIVTQENTSDLCHQVA
KQLLEKSGKQASEIDFILVATVTPDFNMPSVACQVQGAIGATEAFAFDISAACSGFVYAL
SMAEKLVLSGRYQTGLVIGGETFSKMLDWTDRSTAVLFGDGAAGVLIEAAETPHFLNEKL
QADGQRWAALTSGYTINESPFYQGHKQASKTLQMEGRSIFDFAIKDVSQNILSLVTDETV
DYLLLHQANVRIIDKIARKTKISREKFLTNMDKYGNTSAASIPILLDEAVENGTLILGSQ
QRVVLTGFGGGLTWGSLLLTL
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| BDBM23572 |
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| n/a |
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| Name | BDBM23572 |
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| Synonyms: | 2-{[3-(diethylsulfamoyl)-4-phenylbenzene]amido}benzoic acid | Diethylsulfonamide Derivative, 13b |
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| Type | Small organic molecule |
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| Emp. Form. | C24H24N2O5S |
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| Mol. Mass. | 452.523 |
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| SMILES | CCN(CC)S(=O)(=O)c1cc(ccc1-c1ccccc1)C(=O)Nc1ccccc1C(O)=O |
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| Structure | 
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