| Reaction Details |
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 | Report a problem with these data |
| Target | Neuromedin-K receptor |
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| Ligand | BDBM50412949 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_515484 (CHEMBL992211) |
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| Ki | 6.31±n/a nM |
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| Citation |  Smith, PW; Wyman, PA; Lovell, P; Goodacre, C; Serafinowska, HT; Vong, A; Harrington, F; Flynn, S; Bradley, DM; Porter, R; Coggon, S; Murkitt, G; Searle, K; Thomas, DR; Watson, JM; Martin, W; Wu, Z; Dawson, LA New quinoline NK3 receptor antagonists with CNS activity. Bioorg Med Chem Lett19:837-40 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Neuromedin-K receptor |
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| Name: | Neuromedin-K receptor |
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| Synonyms: | NK-3 receptor | NK-3R | NK3R | NK3R_HUMAN | NKR | Neurokinin 3 receptor | Neurokinin B receptor | Neurokinin-3 (NK-3) | Neuromedin-3 receptor (NK-3R) | Neuromedin-3 receptor (NK3) | Neuromedin-K receptor | Neuromedin-K receptor (NK-3 receptor) | Neuromedin-K receptor (NK3) | Neuromedin-K receptor(NK3R) | TAC3R | TACR3 | Tachykinin receptor 3 | Tachykinin receptor 3 (NK3) |
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| Type: | Enzyme |
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| Mol. Mass.: | 52221.96 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P29371 |
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| Residue: | 465 |
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| Sequence: | MATLPAAETWIDGGGGVGADAVNLTASLAAGAATGAVETGWLQLLDQAGNLSSSPSALGL
PVASPAPSQPWANLTNQFVQPSWRIALWSLAYGVVVAVAVLGNLIVIWIILAHKRMRTVT
NYFLVNLAFSDASMAAFNTLVNFIYALHSEWYFGANYCRFQNFFPITAVFASIYSMTAIA
VDRYMAIIDPLKPRLSATATKIVIGSIWILAFLLAFPQCLYSKTKVMPGRTLCFVQWPEG
PKQHFTYHIIVIILVYCFPLLIMGITYTIVGITLWGGEIPGDTCDKYHEQLKAKRKVVKM
MIIVVMTFAICWLPYHIYFILTAIYQQLNRWKYIQQVYLASFWLAMSSTMYNPIIYCCLN
KRFRAGFKRAFRWCPFIKVSSYDELELKTTRFHPNRQSSMYTVTRMESMTVVFDPNDADT
TRSSRKKRATPRDPSFNGCSRRNSKSASATSSFISSPYTSVDEYS
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| BDBM50412949 |
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| n/a |
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| Name | BDBM50412949 |
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| Synonyms: | CHEMBL519790 |
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| Type | Small organic molecule |
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| Emp. Form. | C26H21F2N3O |
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| Mol. Mass. | 429.4612 |
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| SMILES | Nc1c(nc2ccccc2c1C(=O)N[C@@H](C1CC1)c1cccc(F)c1)-c1cccc(F)c1 |r| |
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| Structure | 
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