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TargetC5a anaphylatoxin chemotactic receptor 1
LigandBDBM50413241
Substrate/Competitorn/a
Meas. Tech.ChEMBL_541063 (CHEMBL1024763)
IC50 19.95±n/a nM
Citation Sanganee, HJBaxter, ABarber, SBrown, AJGrice, DHunt, FKing, SLaughton, DPairaudeau, GThong, BWeaver, RUnitt, J Discovery of small molecule human C5a receptor antagonists. Bioorg Med Chem Lett19:1143-7 (2009) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
C5a anaphylatoxin chemotactic receptor 1
Name:C5a anaphylatoxin chemotactic receptor 1
Synonyms:C5AR | C5AR1 | C5AR1_HUMAN | C5R1 | C5a anaphylatoxin chemotactic receptor | C5a anaphylatoxin chemotactic receptor (C5aR) | C5a-R | CD_antigen=CD88
Type:Enzyme
Mol. Mass.:39347.68
Organism:Homo sapiens (Human)
Description:P21730
Residue:350
Sequence:
MDSFNYTTPDYGHYDDKDTLDLNTPVDKTSNTLRVPDILALVIFAVVFLVGVLGNALVVW
VTAFEAKRTINAIWFLNLAVADFLSCLALPILFTSIVQHHHWPFGGAACSILPSLILLNM
YASILLLATISADRFLLVFKPIWCQNFRGAGLAWIACAVAWGLALLLTIPSFLYRVVREE
YFPPKVLCGVDYSHDKRRERAVAIVRLVLGFLWPLLTLTICYTFILLRTWSRRATRSTKT
LKVVVAVVASFFIFWLPYQVTGIMMSFLEPSSPTFLLLKKLDSLCVSFAYINCCINPIIY
VVAGQGFQGRLRKSLPSLLRNVLTEESVVRESKSFTRSTVDTMAQKTQAV
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50413241
n/a
NameBDBM50413241
Synonyms:CHEMBL513412
TypeSmall organic molecule
Emp. Form.C25H27FN2O6
Mol. Mass.470.4901
SMILESCOc1ccc(N(C(C(=O)NC[C@@H](C)O)c2ccccc2F)C(=O)c2occc2C)c(OC)c1 |r|
Structure
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