| Reaction Details |
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 | Report a problem with these data |
| Target | Neuronal acetylcholine receptor subunit alpha-4 |
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| Ligand | BDBM50088458 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_562742 (CHEMBL1022414) |
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| IC50 | 6.76±n/a nM |
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| Citation |  Tosco, P; Ahring, PK; Dyhring, T; Peters, D; Harpsøe, K; Liljefors, T; Balle, T Complementary three-dimensional quantitative structure-activity relationship modeling of binding affinity and functional potency: a study on alpha4beta2 nicotinic ligands. J Med Chem52:2311-6 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Neuronal acetylcholine receptor subunit alpha-4 |
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| Name: | Neuronal acetylcholine receptor subunit alpha-4 |
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| Synonyms: | ACHA4_HUMAN | CHRNA4 | CHRNA4 protein | NACRA4 | Neuronal acetylcholine receptor protein alpha-4 subunit | Neuronal acetylcholine receptor subunit alpha 4 beta 2 | Nicotinic acetylcholine receptor alpha4/beta2/alpha5 |
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| Type: | n/a |
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| Mol. Mass.: | 69963.49 |
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| Organism: | Homo sapiens (Human) |
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| Description: | NACHRA4 |
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| Residue: | 627 |
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| Sequence: | MELGGPGAPRLLPPLLLLLGTGLLRASSHVETRAHAEERLLKKLFSGYNKWSRPVANISD
VVLVRFGLSIAQLIDVDEKNQMMTTNVWVKQEWHDYKLRWDPADYENVTSIRIPSELIWR
PDIVLYNNADGDFAVTHLTKAHLFHDGRVQWTPPAIYKSSCSIDVTFFPFDQQNCTMKFG
SWTYDKAKIDLVNMHSRVDQLDFWESGEWVIVDAVGTYNTRKYECCAEIYPDITYAFVIR
RLPLFYTINLIIPCLLISCLTVLVFYLPSECGEKITLCISVLLSLTVFLLLITEIIPSTS
LVIPLIGEYLLFTMIFVTLSIVITVFVLNVHHRSPRTHTMPTWVRRVFLDIVPRLLLMKR
PSVVKDNCRRLIESMHKMASAPRFWPEPEGEPPATSGTQSLHPPSPSFCVPLDVPAEPGP
SCKSPSDQLPPQQPLEAEKASPHPSPGPCRPPHGTQAPGLAKARSLSVQHMSSPGEAVEG
GVRCRSRSIQYCVPRDDAAPEADGQAAGALASRNTHSAELPPPDQPSPCKCTCKKEPSSV
SPSATVKTRSTKAPPPHLPLSPALTRAVEGVQYIADHLKAEDTDFSVKEDWKYVAMVIDR
IFLWMFIIVCLLGTVGLFLPPWLAGMI
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| BDBM50088458 |
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| n/a |
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| Name | BDBM50088458 |
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| Synonyms: | 3-(pyridin-3-yl)-8-azabicyclo[3.2.1]oct-3-ene | 3-Pyridin-3-yl-8-aza-bicyclo[3.2.1]oct-2-ene | CHEMBL62765 |
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| Type | Small organic molecule |
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| Emp. Form. | C12H14N2 |
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| Mol. Mass. | 186.253 |
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| SMILES | C1CC2NC1CC(=C2)c1cccnc1 |c:7,TLB:8:6:3:1.0,(15.36,3.68,;16.53,2.97,;15.55,4.31,;15.81,5.85,;14.76,5.01,;13,5.05,;12.74,3.5,;13.71,4.31,;11.4,2.74,;10.07,3.5,;8.74,2.73,;8.74,1.19,;10.07,.42,;11.41,1.19,)| |
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| Structure | 
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