| Reaction Details |
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 | Report a problem with these data |
| Target | Histamine H4 receptor |
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| Ligand | BDBM50413501 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_562955 (CHEMBL1015354) |
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| EC50 | 8.1±n/a nM |
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| Citation |  Igel, P; Schneider, E; Schnell, D; Elz, S; Seifert, R; Buschauer, A N(G)-acylated imidazolylpropylguanidines as potent histamine H4 receptor agonists: selectivity by variation of the N(G)-substituent. J Med Chem52:2623-7 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Histamine H4 receptor |
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| Name: | Histamine H4 receptor |
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| Synonyms: | AXOR35 | G-protein coupled receptor 105 | GPCR105 | GPRv53 | HH4R | HISTAMINE H4 | HRH4 | HRH4_HUMAN | Histamine H4 receptor | Histamine H4 receptor (H4R) | Histamine receptor (H3 and H4) | Pfi-013 | SP9144 |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 44517.02 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Binding assays were using CHO cells stably expressing hH4R receptors. |
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| Residue: | 390 |
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| Sequence: | MPDTNSTINLSLSTRVTLAFFMSLVAFAIMLGNALVILAFVVDKNLRHRSSYFFLNLAIS
DFFVGVISIPLYIPHTLFEWDFGKEICVFWLTTDYLLCTASVYNIVLISYDRYLSVSNAV
SYRTQHTGVLKIVTLMVAVWVLAFLVNGPMILVSESWKDEGSECEPGFFSEWYILAITSF
LEFVIPVILVAYFNMNIYWSLWKRDHLSRCQSHPGLTAVSSNICGHSFRGRLSSRRSLSA
STEVPASFHSERQRRKSSLMFSSRTKMNSNTIASKMGSFSQSDSVALHQREHVELLRARR
LAKSLAILLGVFAVCWAPYSLFTIVLSFYSSATGPKSVWYRIAFWLQWFNSFVNPLLYPL
CHKRFQKAFLKIFCIKKQPLPSQHSRSVSS
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| BDBM50413501 |
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| n/a |
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| Name | BDBM50413501 |
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| Synonyms: | CHEMBL325327 | SK&F-91486 | SK-91486 |
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| Type | Small organic molecule |
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| Emp. Form. | C7H13N5 |
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| Mol. Mass. | 167.2116 |
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| SMILES | NC(N)=NCCCc1cnc[nH]1 |(34.52,3.88,;33.18,4.65,;33.18,6.19,;31.85,3.88,;30.52,4.65,;29.18,3.88,;27.85,4.65,;26.51,3.88,;26.53,2.34,;25.07,1.85,;24.15,3.09,;25.05,4.34,)| |
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| Structure | 
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