| Reaction Details |
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 | Report a problem with these data |
| Target | Serine/threonine-protein kinase Chk1 |
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| Ligand | BDBM50214562 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_570759 (CHEMBL1026934) |
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| Ki | 0.100000±n/a nM |
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| Citation |  Brown, SP; Muchmore, SW Large-scale application of high-throughput molecular mechanics with Poisson-Boltzmann surface area for routine physics-based scoring of protein-ligand complexes. J Med Chem52:3159-65 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Serine/threonine-protein kinase Chk1 |
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| Name: | Serine/threonine-protein kinase Chk1 |
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| Synonyms: | CHEK1 | CHK1 | CHK1 checkpoint homolog | CHK1_HUMAN | Checkpoint kinase-1 (CHK1) |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 54443.02 |
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| Organism: | Homo sapiens (Human) |
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| Description: | gi_166295192 |
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| Residue: | 476 |
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| Sequence: | MAVPFVEDWDLVQTLGEGAYGEVQLAVNRVTEEAVAVKIVDMKRAVDCPENIKKEICINK
MLNHENVVKFYGHRREGNIQYLFLEYCSGGELFDRIEPDIGMPEPDAQRFFHQLMAGVVY
LHGIGITHRDIKPENLLLDERDNLKISDFGLATVFRYNNRERLLNKMCGTLPYVAPELLK
RREFHAEPVDVWSCGIVLTAMLAGELPWDQPSDSCQEYSDWKEKKTYLNPWKKIDSAPLA
LLHKILVENPSARITIPDIKKDRWYNKPLKKGAKRPRVTSGGVSESPSGFSKHIQSNLDF
SPVNSASSEENVKYSSSQPEPRTGLSLWDTSPSYIDKLVQGISFSQPTCPDHMLLNSQLL
GTPGSSQNPWQRLVKRMTRFFTKLDADKSYQCLKETCEKLGYQWKKSCMNQVTISTTDRR
NNKLIFKVNLLEMDDKILVDFRLSKGDGLEFKRHFLKIKGKLIDIVSSQKIWLPAT
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| BDBM50214562 |
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| n/a |
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| Name | BDBM50214562 |
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| Synonyms: | 2-(3-(4'-hydroxybiphenyl-4-yl)-7-methoxy-1,4-dihydroindeno[1,2-c]pyrazol-6-yloxy)propane-1,3-diol | 2-[3-(4'-hydroxy-biphenyl-4-yl)-7-methoxy-2,4-dihydro-indeno[1,2-c]pyrazol-6-yloxy]-propane-1,3-diol | CHEMBL248194 |
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| Type | Small organic molecule |
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| Emp. Form. | C26H24N2O5 |
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| Mol. Mass. | 444.4792 |
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| SMILES | COc1cc-2c(Cc3c(n[nH]c-23)-c2ccc(cc2)-c2ccc(O)cc2)cc1OC(CO)CO |
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| Structure | 
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