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TargetUrokinase-type plasminogen activator
LigandBDBM50138673
Substrate/Competitorn/a
Meas. Tech.ChEMBL_570757
Ki 6.3±n/a nM
Citation Brown SPMuchmore SW Large-scale application of high-throughput molecular mechanics with Poisson-Boltzmann surface area for routine physics-based scoring of protein-ligand complexes. J Med Chem 52:3159-65 (2009) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Urokinase-type plasminogen activator
Name:Urokinase-type plasminogen activator/surface receptor
Synonyms:U-plasminogen activator | Urokinase | Urokinase-type plasminogen activator (uPA)
Type:Enzyme
Mol. Mass.:48528.62
Organism:Homo sapiens (Human)
Description:P00749
Residue:431
Sequence:
MRALLARLLLCVLVVSDSKGSNELHQVPSNCDCLNGGTCVSNKYFSNIHWCNCPKKFGGQ
HCEIDKSKTCYEGNGHFYRGKASTDTMGRPCLPWNSATVLQQTYHAHRSDALQLGLGKHN
YCRNPDNRRRPWCYVQVGLKPLVQECMVHDCADGKKPSSPPEELKFQCGQKTLRPRFKII
GGEFTTIENQPWFAAIYRRHRGGSVTYVCGGSLISPCWVISATHCFIDYPKKEDYIVYLG
RSRLNSNTQGEMKFEVENLILHKDYSADTLAHHNDIALLKIRSKEGRCAQPSRTIQTICL
PSMYNDPQFGTSCEITGFGKENSTDYLYPEQLKMTVVKLISHRECQQPHYYGSEVTTKML
CAADPQWKTDSCQGDSGGPLVCSLQGRMTLTGIVSWGRGCALKDKPGVYTRVSHFLPWIR
SHTKEENGLAL
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  Blast E-value cutoff:
BDBM50138673
n/a
NameBDBM50138673
Synonyms:6-Carbamimidoyl-naphthalene-2-carboxylic acid (4-ethyl-1,2,3,4-tetrahydro-isoquinolin-6-yl)-amide | 6-carbamimidoyl-N-(4-ethyl-1,2,3,4-tetrahydroisoquinolin-6-yl)-2-naphthamide | CHEMBL108447
TypeSmall organic molecule
Emp. Form.C23H24N4O
Mol. Mass.372.4629
SMILESCCC1CNCc2ccc(NC(=O)c3ccc4cc(ccc4c3)C(N)=N)cc12
Structure
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