| Reaction Details |
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 | Report a problem with these data |
| Target | Histamine receptor (H3) |
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| Ligand | BDBM50414390 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_576568 |
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| Ki | 5.01±n/a nM |
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| Citation |  Lim HD; Istyastono EP; van de Stolpe A; Romeo G; Gobbi S; Schepers M; Lahaye R; Menge WM; Zuiderveld OP; Jongejan A; Smits RA; Bakker RA; Haaksma EE; Leurs R; de Esch IJ Clobenpropit analogs as dual activity ligands for the histamine H3 and H4 receptors: synthesis, pharmacological evaluation, and cross-target QSAR studies. Bioorg Med Chem 17:3987-94 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Histamine receptor (H3) |
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| Name: | Histamine receptor (H3 and H4) |
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| Synonyms: | G-protein coupled receptor 97 | HH3R | HISTAMINE H3 | HRH3 | Histamine H3 Receptor | Histamine H3 receptor (H3) | Histamine H3L | Histamine receptor (H3 and H4) |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 48691.47 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Binding assays were using CHO cells stably expressing hH3R receptors. |
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| Residue: | 445 |
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| Sequence: | MERAPPDGPLNASGALAGEAAAAGGARGFSAAWTAVLAALMALLIVATVLGNALVMLAFV
ADSSLRTQNNFFLLNLAISDFLVGAFCIPLYVPYVLTGRWTFGRGLCKLWLVVDYLLCTS
SAFNIVLISYDRFLSVTRAVSYRAQQGDTRRAVRKMLLVWVLAFLLYGPAILSWEYLSGG
SSIPEGHCYAEFFYNWYFLITASTLEFFTPFLSVTFFNLSIYLNIQRRTRLRLDGAREAA
GPEPPPEAQPSPPPPPGCWGCWQKGHGEAMPLHRYGVGEAAVGAEAGEATLGGGGGGGSV
ASPTSSSGSSSRGTERPRSLKRGSKPSASSASLEKRMKMVSQSFTQRFRLSRDRKVAKSL
AVIVSIFGLCWAPYTLLMIIRAACHGHCVPDYWYETSFWLLWANSAVNPVLYPLCHHSFR
RAFTKLLCPQKLKIQPHSSLEHCWK
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| BDBM50414390 |
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| n/a |
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| Name | BDBM50414390 |
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| Synonyms: | CHEMBL1202328 |
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| Type | Small organic molecule |
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| Emp. Form. | C14H17FN4S |
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| Mol. Mass. | 292.375 |
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| SMILES | NC(SCCCc1cnc[nH]1)=NCc1ccc(F)cc1 |w:11.12| |
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| Structure | 
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