Ki Summary BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetProcathepsin L
LigandBDBM50414639
Substrate/Competitorn/a
Meas. Tech.ChEMBL_581585 (CHEMBL1062472)
IC50 5.01±n/a nM
Citation Bethel, PAGerhardt, SJones, EVKenny, PWKaroutchi, GIMorley, ADOldham, KRankine, NAugustin, MKrapp, SSimader, HSteinbacher, S Design of selective Cathepsin inhibitors. Bioorg Med Chem Lett19:4622-5 (2009) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Procathepsin L
Name:Procathepsin L
Synonyms:CATL1_HUMAN | CTSL | CTSL CTSL1 | CTSL1 | Cathepsin L | Cathepsin L1 | Cathepsin L1 heavy chain | Cathepsin L1 light chain | MEP | Major excreted protein | cathepsin L preproprotein
Type:Enzyme
Mol. Mass.:37557.19
Organism:Homo sapiens (Human)
Description:Purchased from Calbiochem (San Diego, CA).
Residue:333
Sequence:
MNPTLILAAFCLGIASATLTFDHSLEAQWTKWKAMHNRLYGMNEEGWRRAVWEKNMKMIE
LHNQEYREGKHSFTMAMNAFGDMTSEEFRQVMNGFQNRKPRKGKVFQEPLFYEAPRSVDW
REKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGRLISLSEQNLVDCSGPQGNEGCNG
GLMDYAFQYVQDNGGLDSEESYPYEATEESCKYNPKYSVANDTGFVDIPKQEKALMKAVA
TVGPISVAIDAGHESFLFYKEGIYFEPDCSSEDMDHGVLVVGYGFESTESDNNKYWLVKN
SWGEEWGMGGYVKMAKDRRNHCGIASAASYPTV
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50414639
n/a
NameBDBM50414639
Synonyms:CHEMBL550872
TypeSmall organic molecule
Emp. Form.C23H27N7O3
Mol. Mass.449.5056
SMILESCc1nnc(o1)-c1cccc(CC(NC(=O)c2cc(nn2C)C(C)(C)C)C(=O)NCC#N)c1
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: