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TargetProcathepsin L
LigandBDBM50414644
Substrate/Competitorn/a
Meas. Tech.ChEMBL_581585 (CHEMBL1062472)
IC50 1.26±n/a nM
Citation Bethel, PAGerhardt, SJones, EVKenny, PWKaroutchi, GIMorley, ADOldham, KRankine, NAugustin, MKrapp, SSimader, HSteinbacher, S Design of selective Cathepsin inhibitors. Bioorg Med Chem Lett19:4622-5 (2009) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Procathepsin L
Name:Procathepsin L
Synonyms:CATL1_HUMAN | CTSL | CTSL CTSL1 | CTSL1 | Cathepsin L | Cathepsin L1 | Cathepsin L1 heavy chain | Cathepsin L1 light chain | MEP | Major excreted protein | cathepsin L preproprotein
Type:Enzyme
Mol. Mass.:37557.19
Organism:Homo sapiens (Human)
Description:Purchased from Calbiochem (San Diego, CA).
Residue:333
Sequence:
MNPTLILAAFCLGIASATLTFDHSLEAQWTKWKAMHNRLYGMNEEGWRRAVWEKNMKMIE
LHNQEYREGKHSFTMAMNAFGDMTSEEFRQVMNGFQNRKPRKGKVFQEPLFYEAPRSVDW
REKGYVTPVKNQGQCGSCWAFSATGALEGQMFRKTGRLISLSEQNLVDCSGPQGNEGCNG
GLMDYAFQYVQDNGGLDSEESYPYEATEESCKYNPKYSVANDTGFVDIPKQEKALMKAVA
TVGPISVAIDAGHESFLFYKEGIYFEPDCSSEDMDHGVLVVGYGFESTESDNNKYWLVKN
SWGEEWGMGGYVKMAKDRRNHCGIASAASYPTV
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50414644
n/a
NameBDBM50414644
Synonyms:CHEMBL555122
TypeSmall organic molecule
Emp. Form.C24H30N8O3
Mol. Mass.478.5468
SMILESCn1nc(cc1C(=O)NC(Cc1cccc(c1)-c1nnc(CCN)o1)C(=O)NCC#N)C(C)(C)C
Structure
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