| Reaction Details |
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 | Report a problem with these data |
| Target | Coproporphyrinogen III oxidase |
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| Ligand | BDBM50414834 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_588025 (CHEMBL1048360) |
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| Ki | 12.88±n/a nM |
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| Citation |  Zhang, L; Hao, GF; Tan, Y; Xi, Z; Huang, MZ; Yang, GF Bioactive conformation analysis of cyclic imides as protoporphyrinogen oxidase inhibitor by combining DFT calculations, QSAR and molecular dynamic simulations. Bioorg Med Chem17:4935-42 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Coproporphyrinogen III oxidase |
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| Name: | Coproporphyrinogen III oxidase |
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| Synonyms: | CGOX_BACSU | PPO | Protoporphyrinogen oxidase | cgoX | hemG | hemY |
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| Type: | PROTEIN |
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| Mol. Mass.: | 51210.88 |
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| Organism: | Bacillus subtilis (strain 168) |
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| Description: | ChEMBL_588025 |
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| Residue: | 470 |
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| Sequence: | MSDGKKHVVIIGGGITGLAAAFYMEKEIKEKNLPLELTLVEASPRVGGKIQTVKKDGYII
ERGPDSFLERKKSAPQLVKDLGLEHLLVNNATGQSYVLVNRTLHPMPKGAVMGIPTKIAP
FVSTGLFSLSGKARAAMDFILPASKTKDDQSLGEFFRRRVGDEVVENLIEPLLSGIYAGD
IDKLSLMSTFPQFYQTEQKHRSLILGMKKTRPQGSGQQLTAKKQGQFQTLSTGLQTLVEE
IEKQLKLTKVYKGTKVTKLSHSGSCYSLELDNGVTLDADSVIVTAPHKAAAGMLSELPAI
SHLKNMHSTSVANVALGFPEGSVQMEHEGTGFVISRNSDFAITACTWTNKKWPHAAPEGK
TLLRAYVGKAGDESIVDLSDNDIINIVLEDLKKVMNINGEPEMTCVTRWHESMPQYHVGH
KQRIKELREALASAYPGVYMTGASFEGVGIPDCIDQGKAAVSDALTYLFS
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| BDBM50414834 |
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| n/a |
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| Name | BDBM50414834 |
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| Synonyms: | CHEMBL573884 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H15Cl3FN3O4 |
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| Mol. Mass. | 510.73 |
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| SMILES | Fc1cc(Cl)c(NC(=O)NC(=O)c2c(Cl)cccc2Cl)cc1N1C(=O)C2=C(CCCC2)C1=O |t:27| |
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| Structure | 
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