| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Eukaryotic translation initiation factor 2-alpha kinase 1 |
|---|
| Ligand | BDBM50414879 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_589403 (CHEMBL1058424) |
|---|
| IC50 | 794.33±n/a nM |
|---|
| Citation |  Rosen, MD; Woods, CR; Goldberg, SD; Hack, MD; Bounds, AD; Yang, Y; Wagaman, PC; Phuong, VK; Ameriks, AP; Barrett, TD; Kanelakis, KC; Chuang, JC; Chang, J; Shankley, NP; Rabinowitz, MH Discovery of the first known small-molecule inhibitors of heme-regulated eukaryotic initiation factor 2alpha (HRI) kinase. Bioorg Med Chem Lett19:6548-51 (2009) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Eukaryotic translation initiation factor 2-alpha kinase 1 |
|---|
| Name: | Eukaryotic translation initiation factor 2-alpha kinase 1 |
|---|
| Synonyms: | E2AK1_HUMAN | EIF2AK1 | HRI | KIAA1369 |
|---|
| Type: | PROTEIN |
|---|
| Mol. Mass.: | 71098.55 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | ChEMBL_1467744 |
|---|
| Residue: | 630 |
|---|
| Sequence: | MQGGNSGVRKREEEGDGAGAVAAPPAIDFPAEGPDPEYDESDVPAEIQVLKEPLQQPTFP
FAVANQLLLVSLLEHLSHVHEPNPLRSRQVFKLLCQTFIKMGLLSSFTCSDEFSSLRLHH
NRAITHLMRSAKERVRQDPCEDISRIQKIRSREVALEAQTSRYLNEFEELAILGKGGYGR
VYKVRNKLDGQYYAIKKILIKGATKTVCMKVLREVKVLAGLQHPNIVGYHTAWIEHVHVI
QPRADRAAIELPSLEVLSDQEEDREQCGVKNDESSSSSIIFAEPTPEKEKRFGESDTENQ
NNKSVKYTTNLVIRESGELESTLELQENGLAGLSASSIVEQQLPLRRNSHLEESFTSTEE
SSEENVNFLGQTEAQYHLMLHIQMQLCELSLWDWIVERNKRGREYVDESACPYVMANVAT
KIFQELVEGVFYIHNMGIVHRDLKPRNIFLHGPDQQVKIGDFGLACTDILQKNTDWTNRN
GKRTPTHTSRVGTCLYASPEQLEGSEYDAKSDMYSLGVVLLELFQPFGTEMERAEVLTGL
RTGQLPESLRKRCPVQAKYIQHLTRRNSSQRPSAIQLLQSELFQNSGNVNLTLQMKIIEQ
EKEIAELKKQLNLLSQDKGVRDDGKDGGVG
|
|
|
|---|
| BDBM50414879 |
|---|
| n/a |
|---|
| Name | BDBM50414879 |
|---|
| Synonyms: | CHEMBL573280 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C18H15BrClN3 |
|---|
| Mol. Mass. | 388.689 |
|---|
| SMILES | Cc1cccc(Cl)c1CNc1[nH]nc-2c1Cc1ccc(Br)cc-21 |
|---|
| Structure | 
|
|---|
Search and Browse
