| Reaction Details |
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 | Report a problem with these data |
| Target | Eukaryotic translation initiation factor 2-alpha kinase 1 |
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| Ligand | BDBM50414894 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_589403 (CHEMBL1058424) |
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| IC50 | 6.31±n/a nM |
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| Citation |  Rosen, MD; Woods, CR; Goldberg, SD; Hack, MD; Bounds, AD; Yang, Y; Wagaman, PC; Phuong, VK; Ameriks, AP; Barrett, TD; Kanelakis, KC; Chuang, JC; Chang, J; Shankley, NP; Rabinowitz, MH Discovery of the first known small-molecule inhibitors of heme-regulated eukaryotic initiation factor 2alpha (HRI) kinase. Bioorg Med Chem Lett19:6548-51 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Eukaryotic translation initiation factor 2-alpha kinase 1 |
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| Name: | Eukaryotic translation initiation factor 2-alpha kinase 1 |
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| Synonyms: | E2AK1_HUMAN | EIF2AK1 | HRI | KIAA1369 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 71098.55 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1467744 |
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| Residue: | 630 |
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| Sequence: | MQGGNSGVRKREEEGDGAGAVAAPPAIDFPAEGPDPEYDESDVPAEIQVLKEPLQQPTFP
FAVANQLLLVSLLEHLSHVHEPNPLRSRQVFKLLCQTFIKMGLLSSFTCSDEFSSLRLHH
NRAITHLMRSAKERVRQDPCEDISRIQKIRSREVALEAQTSRYLNEFEELAILGKGGYGR
VYKVRNKLDGQYYAIKKILIKGATKTVCMKVLREVKVLAGLQHPNIVGYHTAWIEHVHVI
QPRADRAAIELPSLEVLSDQEEDREQCGVKNDESSSSSIIFAEPTPEKEKRFGESDTENQ
NNKSVKYTTNLVIRESGELESTLELQENGLAGLSASSIVEQQLPLRRNSHLEESFTSTEE
SSEENVNFLGQTEAQYHLMLHIQMQLCELSLWDWIVERNKRGREYVDESACPYVMANVAT
KIFQELVEGVFYIHNMGIVHRDLKPRNIFLHGPDQQVKIGDFGLACTDILQKNTDWTNRN
GKRTPTHTSRVGTCLYASPEQLEGSEYDAKSDMYSLGVVLLELFQPFGTEMERAEVLTGL
RTGQLPESLRKRCPVQAKYIQHLTRRNSSQRPSAIQLLQSELFQNSGNVNLTLQMKIIEQ
EKEIAELKKQLNLLSQDKGVRDDGKDGGVG
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| BDBM50414894 |
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| n/a |
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| Name | BDBM50414894 |
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| Synonyms: | CHEMBL573760 |
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| Type | Small organic molecule |
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| Emp. Form. | C19H15Cl2N3O3 |
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| Mol. Mass. | 404.247 |
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| SMILES | COc1cc2C(=O)c3c(NCc4c(Cl)cccc4Cl)[nH]nc3-c2cc1OC |
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| Structure | 
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