| Reaction Details |
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 | Report a problem with these data |
| Target | C-C chemokine receptor type 8 |
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| Ligand | BDBM50414974 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_594037 (CHEMBL1045844) |
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| IC50 | 2.63±n/a nM |
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| Citation |  Shamovsky, I; de Graaf, C; Alderin, L; Bengtsson, M; Bladh, H; Börjesson, L; Connolly, S; Dyke, HJ; van den Heuvel, M; Johansson, H; Josefsson, BG; Kristoffersson, A; Linnanen, T; Lisius, A; Männikkö, R; Nordén, B; Price, S; Ripa, L; Rognan, D; Rosendahl, A; Skrinjar, M; Urbahns, K Increasing selectivity of CC chemokine receptor 8 antagonists by engineering nondesolvation related interactions with the intended and off-target binding sites. J Med Chem52:7706-23 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| C-C chemokine receptor type 8 |
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| Name: | C-C chemokine receptor type 8 |
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| Synonyms: | CCR8 | CCR8_HUMAN | CKRL1 | CMKBR8 | CMKBRL2 |
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| Type: | PROTEIN |
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| Mol. Mass.: | 40855.53 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_454278 |
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| Residue: | 355 |
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| Sequence: | MDYTLDLSVTTVTDYYYPDIFSSPCDAELIQTNGKLLLAVFYCLLFVFSLLGNSLVILVL
VVCKKLRSITDVYLLNLALSDLLFVFSFPFQTYYLLDQWVFGTVMCKVVSGFYYIGFYSS
MFFITLMSVDRYLAVVHAVYALKVRTIRMGTTLCLAVWLTAIMATIPLLVFYQVASEDGV
LQCYSFYNQQTLKWKIFTNFKMNILGLLIPFTIFMFCYIKILHQLKRCQNHNKTKAIRLV
LIVVIASLLFWVPFNVVLFLTSLHSMHILDGCSISQQLTYATHVTEIISFTHCCVNPVIY
AFVGEKFKKHLSEIFQKSCSQIFNYLGRQMPRESCEKSSSCQQHSSRSSSVDYIL
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| BDBM50414974 |
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| n/a |
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| Name | BDBM50414974 |
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| Synonyms: | CHEMBL568523 |
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| Type | Small organic molecule |
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| Emp. Form. | C26H34N4O2 |
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| Mol. Mass. | 434.5738 |
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| SMILES | CC1(C)Cc2cccc(CN3CCC4(CC3)CCN(CC4)C(=O)c3ccc(N)cn3)c2O1 |
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| Structure | 
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