| Reaction Details |
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 | Report a problem with these data |
| Target | D(3) dopamine receptor |
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| Ligand | BDBM50331549 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_598577 (CHEMBL1043569) |
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| Ki | 0.794±n/a nM |
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| Citation |  Bennacef, I; Salinas, CA; Bonasera, TA; Gunn, RN; Audrain, H; Jakobsen, S; Nabulsi, N; Weinzimmer, D; Carson, RE; Huang, Y; Holmes, I; Micheli, F; Heidbreder, C; Gentile, G; Rossi, T; Laruelle, M Dopamine D3 receptor antagonists: the quest for a potentially selective PET ligand. Part 3: Radiosynthesis and in vivo studies. Bioorg Med Chem Lett19:5056-9 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| D(3) dopamine receptor |
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| Name: | D(3) dopamine receptor |
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| Synonyms: | DOPAMINE D3 | DRD3_RAT | Dopamine D3 receptor | Drd3 |
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| Type: | Protein |
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| Mol. Mass.: | 49540.58 |
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| Organism: | Rattus norvegicus (Rat) |
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| Description: | P19020 |
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| Residue: | 446 |
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| Sequence: | MAPLSQISTHLNSTCGAENSTGVNRARPHAYYALSYCALILAIIFGNGLVCAAVLRERAL
QTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILN
LCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTTGDPSI
CSISNPDFVIYSSVVSFYVPFGVTVLVYARIYIVLRQRQRKRILTRQNSQCISIRPGFPQ
QSSCLRLHPIRQFSIRARFLSDATGQMEHIEDKQYPQKCQDPLLSHLQPPSPGQTHGGLK
RYYSICQDTALRHPSLEGGAGMSPVERTRNSLSPTMAPKLSLEVRKLSNGRLSTSLRLGP
LQPRGVPLREKKATQMVVIVLGAFIVCWLPFFLTHVLNTHCQACHVSPELYRATTWLGYV
NSALNPVIYTTFNVEFRKAFLKILSC
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| BDBM50331549 |
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| n/a |
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| Name | BDBM50331549 |
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| Synonyms: | CHEMBL567286 | [11C]-3-(2-oxo-3-(2-(4-(trifluoromethyl)piperidin-1-yl)ethyl)imidazolidin-1-yl)benzonitrile |
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| Type | Small organic molecule |
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| Emp. Form. | C18H21F3N4O |
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| Mol. Mass. | 366.3807 |
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| SMILES | FC(F)(F)C1CCN(CCN2CCN(C2=O)c2cccc(c2)C#N)CC1 |
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| Structure | 
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