| Reaction Details |
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 | Report a problem with these data |
| Target | D(3) dopamine receptor |
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| Ligand | BDBM50414574 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_598588 (CHEMBL1044429) |
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| Ki | 1.26±n/a nM |
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| Citation |  Bennacef, I; Salinas, CA; Bonasera, TA; Gunn, RN; Audrain, H; Jakobsen, S; Nabulsi, N; Weinzimmer, D; Carson, RE; Huang, Y; Holmes, I; Micheli, F; Heidbreder, C; Gentile, G; Rossi, T; Laruelle, M Dopamine D3 receptor antagonists: the quest for a potentially selective PET ligand. Part 3: Radiosynthesis and in vivo studies. Bioorg Med Chem Lett19:5056-9 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| D(3) dopamine receptor |
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| Name: | D(3) dopamine receptor |
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| Synonyms: | DOPAMINE D3 | DRD3 | DRD3_HUMAN | Dopamine D3 receptor | Dopamine D3 receptor (D3) | Dopamine D3 receptor (D3R) | Dopamine receptor | Dopamine receptor (D3) | Dopamine receptor D3 |
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| Type: | n/a |
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| Mol. Mass.: | 44243.43 |
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| Organism: | Homo sapiens (Human) |
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| Description: | n/a |
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| Residue: | 400 |
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| Sequence: | MASLSQLSSHLNYTCGAENSTGASQARPHAYYALSYCALILAIVFGNGLVCMAVLKERAL
QTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILN
LCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTTGDPTV
CSISNPDFVIYSSVVSFYLPFGVTVLVYARIYVVLKQRRRKRILTRQNSQCNSVRPGFPQ
QTLSPDPAHLELKRYYSICQDTALGGPGFQERGGELKREEKTRNSLSPTIAPKLSLEVRK
LSNGRLSTSLKLGPLQPRGVPLREKKATQMVAIVLGAFIVCWLPFFLTHVLNTHCQTCHV
SPELYSATTWLGYVNSALNPVIYTTFNIEFRKAFLKILSC
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| BDBM50414574 |
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| n/a |
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| Name | BDBM50414574 |
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| Synonyms: | CHEMBL563580 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H24ClN3O |
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| Mol. Mass. | 333.856 |
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| SMILES | Clc1cccc(c1)N1CCN(CCN2[C@H]3CC[C@@H]2CCC3)C1=O |r,TLB:12:13:19.18.20:16.15| |
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| Structure | 
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