Reaction Details |
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Target | Sigma non-opioid intracellular receptor 1 |
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Ligand | BDBM50064172 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ChEMBL_595183 (CHEMBL1040025) |
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Ki | 0.589±n/a nM |
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Citation | Piergentili, A; Amantini, C; Del Bello, F; Giannella, M; Mattioli, L; Palmery, M; Perfumi, M; Pigini, M; Santoni, G; Tucci, P; Zotti, M; Quaglia, W Novel highly potent and selective sigma 1 receptor antagonists related to spipethiane. J Med Chem53:1261-9 (2010) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Sigma non-opioid intracellular receptor 1 |
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Name: | Sigma non-opioid intracellular receptor 1 |
Synonyms: | Aging-associated gene 8 protein | OPRS1 | SGMR1_HUMAN | SIG-1R | SIGMAR1 | SR-BP | SR31747-binding protein | SRBP | Sigma 1-type opioid receptor | Sigma opioid receptor | Sigma1R | hSigmaR1 |
Type: | Enzyme Catalytic Domain |
Mol. Mass.: | 25124.85 |
Organism: | Homo sapiens (Human) |
Description: | Q99720 |
Residue: | 223 |
Sequence: | MQWAVGRRWAWAALLLAVAAVLTQVVWLWLGTQSFVFQREEIAQLARQYAGLDHELAFSR
LIVELRRLHPGHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSRGHSGRY
WAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPS
TLAFALADTVFSTQDFLTLFYTLRSYARGLRLELTTYLFGQDP
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BDBM50064172 |
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n/a |
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Name | BDBM50064172 |
Synonyms: | 1-benzylspiro[hexahydropyridine-4,2'-(3',4'-dihydro-2'H-thiochromene)] | CHEMBL39900 | SPIPETHIANE |
Type | Small organic molecule |
Emp. Form. | C20H23NS |
Mol. Mass. | 309.468 |
SMILES | C(N1CCC2(CC1)CCc1ccccc1S2)c1ccccc1 |
Structure |
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