| Reaction Details |
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 | Report a problem with these data |
| Target | Histamine H4 receptor |
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| Ligand | BDBM50361015 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_613516 (CHEMBL1074193) |
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| Ki | 1.55±n/a nM |
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| Citation |  Smits, RA; Adami, M; Istyastono, EP; Zuiderveld, OP; van Dam, CM; de Kanter, FJ; Jongejan, A; Coruzzi, G; Leurs, R; de Esch, IJ Synthesis and QSAR of quinazoline sulfonamides as highly potent human histamine H4 receptor inverse agonists. J Med Chem53:2390-400 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Histamine H4 receptor |
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| Name: | Histamine H4 receptor |
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| Synonyms: | HH4R | HRH4_RAT | Hrh4 |
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| Type: | G Protein-Coupled Receptor (GPCR) |
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| Mol. Mass.: | 44045.07 |
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| Organism: | Rattus norvegicus (rat) |
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| Description: | Cell pellets from SK-N-MC cells transfected with rat H4 receptor were used in binding assay. |
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| Residue: | 391 |
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| Sequence: | MSESNGTDVLPLTAQVPLAFLMSLLAFAITIGNAVVILAFVADRNLRHRSNYFFLNLAIS
DFFVGVISIPLYIPHTLFNWNFGSGICMFWLITDYLLCTASVYSIVLISYDRYQSVSNAV
RYRAQHTGILKIVAQMVAVWILAFLVNGPMILASDSWKNSTNTEECEPGFVTEWYILAIT
AFLEFLLPVSLVVYFSVQIYWSLWKRGSLSRCPSHAGFIATSSRGTGHSRRTGLACRTSL
PGLKEPAASLHSESPRGKSSLLVSLRTHMSGSIIAFKVGSFCRSESPVLHQREHVELLRG
RKLARSLAVLLSAFAICWAPYCLFTIVLSTYRRGERPKSIWYSIAFWLQWFNSLINPFLY
PLCHRRFQKAFWKILCVTKQPAPSQTQSVSS
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| BDBM50361015 |
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| n/a |
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| Name | BDBM50361015 |
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| Synonyms: | CHEMBL592379 |
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| Type | Small organic molecule |
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| Emp. Form. | C21H25ClN6O2S |
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| Mol. Mass. | 460.98 |
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| SMILES | CN1CCN(CC1)c1nc(NCCS(=O)(=O)Nc2ccccc2)c2cc(Cl)ccc2n1 |
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| Structure | 
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