| Reaction Details |
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 | Report a problem with these data |
| Target | P2X purinoceptor 4 |
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| Ligand | BDBM50415550 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_612724 |
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| IC50 | >10000±n/a nM |
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| Citation |  Brotherton-Pleiss CE; Dillon MP; Ford AP; Gever JR; Carter DS; Gleason SK; Lin CJ; Moore AG; Thompson AW; Villa M; Zhai Y Discovery and optimization of RO-85, a novel drug-like, potent, and selective P2X3 receptor antagonist. Bioorg Med Chem Lett 20:1031-6 (2010) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| P2X purinoceptor 4 |
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| Name: | P2X purinoceptor 4 |
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| Synonyms: | ATP receptor | P2X4 | Purinergic receptor | Purinergic, P2X4 |
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| Type: | Enzyme Catalytic Domain |
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| Mol. Mass.: | 43374.70 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Purinergic, P2X4 0 HUMAN::Q99571 |
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| Residue: | 388 |
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| Sequence: | MAGCCAALAAFLFEYDTPRIVLIRSRKVGLMNRAVQLLILAYVIGWVFVWEKGYQETDSV
VSSVTTKVKGVAVTNTSKLGFRIWDVADYVIPAQEENSLFVMTNVILTMNQTQGLCPEIP
DATTVCKSDASCTAGSAGTHSNGVSTGRCVAFNGSVKTCEVAAWCPVEDDTHVPQPAFLK
AAENFTLLVKNNIWYPKFNFSKRNILPNITTTYLKSCIYDAKTDPFCPIFRLGKIVENAG
HSFQDMAVEGGIMGIQVNWDCNLDRAASLCLPRYSFRRLDTRDVEHNVSPGYNFRFAKYY
RDLAGNEQRTLIKAYGIRFDIIVFGKAGKFDIIPTMINIGSGLALLGMATVLCDIIVLYC
MKKRLYYREKKYKYVEDYEQGLASELDQ
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| BDBM50415550 |
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| n/a |
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| Name | BDBM50415550 |
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| Synonyms: | CHEMBL599760 | Ro-85 |
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| Type | Small organic molecule |
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| Emp. Form. | C22H27N5O2S |
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| Mol. Mass. | 425.547 |
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| SMILES | C[C@H](CN1CCN(CC1)C(C)=O)NC(=O)c1cc2c(nn(C)c2s1)-c1ccccc1 |r| |
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| Structure | 
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