| Reaction Details |
|---|
 | Report a problem with these data |
| Target | P2X purinoceptor 3 |
|---|
| Ligand | BDBM50415550 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ChEMBL_612711 (CHEMBL1069583) |
|---|
| IC50 | 100±n/a nM |
|---|
| Citation |  Brotherton-Pleiss, CE; Dillon, MP; Ford, AP; Gever, JR; Carter, DS; Gleason, SK; Lin, CJ; Moore, AG; Thompson, AW; Villa, M; Zhai, Y Discovery and optimization of RO-85, a novel drug-like, potent, and selective P2X3 receptor antagonist. Bioorg Med Chem Lett20:1031-6 (2010) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| P2X purinoceptor 3 |
|---|
| Name: | P2X purinoceptor 3 |
|---|
| Synonyms: | ATP receptor | P2RX3_RAT | P2X purinoceptor 3 | P2X3 | P2rx3 | Purinergic receptor | ratp2x3 | ratp2x3 + rsa |
|---|
| Type: | Enzyme Catalytic Domain |
|---|
| Mol. Mass.: | 44397.63 |
|---|
| Organism: | RAT |
|---|
| Description: | Purinergic, P2X3 0 RAT::P49654 |
|---|
| Residue: | 397 |
|---|
| Sequence: | MNCISDFFTYETTKSVVVKSWTIGIINRAVQLLIISYFVGWVFLHEKAYQVRDTAIESSV
VTKVKGFGRYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPENEEKYRCVSDS
QCGPERFPGGGILTGRCVNYSSVLRTCEIQGWCPTEVDTVEMPIMMEAENFTIFIKNSIR
FPLFNFEKGNLLPNLTDKDIKRCRFHPEKAPFCPILRVGDVVKFAGQDFAKLARTGGVLG
IKIGWVCDLDKAWDQCIPKYSFTRLDGVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKA
FGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADHYKARKFEE
VTETTLKGTASTNPVFASDQATVEKQSTDSGAYSIGH
|
|
|
|---|
| BDBM50415550 |
|---|
| n/a |
|---|
| Name | BDBM50415550 |
|---|
| Synonyms: | CHEMBL599760 | Ro-85 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C22H27N5O2S |
|---|
| Mol. Mass. | 425.547 |
|---|
| SMILES | C[C@H](CN1CCN(CC1)C(C)=O)NC(=O)c1cc2c(nn(C)c2s1)-c1ccccc1 |r| |
|---|
| Structure | 
|
|---|
Search and Browse
