| Reaction Details |
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 | Report a problem with these data |
| Target | Aminopeptidase N |
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| Ligand | BDBM50415632 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ChEMBL_619203 (CHEMBL1100889) |
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| Ki | 52.48±n/a nM |
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| Citation |  Lukaszuk, A; Demaegdt, H; Feytens, D; Vanderheyden, P; Vauquelin, G; Tourwé, D The replacement of His(4) in angiotensin IV by conformationally constrained residues provides highly potent and selective analogues. J Med Chem52:5612-8 (2009) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Aminopeptidase N |
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| Name: | Aminopeptidase N |
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| Synonyms: | AMPN_HUMAN | ANPEP | APN | Alanyl aminopeptidase | Aminopeptidase | CD13 | CD_antigen=CD13 | Microsomal aminopeptidase | Myeloid plasma membrane glycoprotein CD13 | PEPN | gp150 | hAPN |
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| Type: | PROTEIN |
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| Mol. Mass.: | 109522.63 |
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| Organism: | Homo sapiens (Human) |
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| Description: | ChEMBL_1507526 |
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| Residue: | 967 |
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| Sequence: | MAKGFYISKSLGILGILLGVAAVCTIIALSVVYSQEKNKNANSSPVASTTPSASATTNPA
SATTLDQSKAWNRYRLPNTLKPDSYRVTLRPYLTPNDRGLYVFKGSSTVRFTCKEATDVI
IIHSKKLNYTLSQGHRVVLRGVGGSQPPDIDKTELVEPTEYLVVHLKGSLVKDSQYEMDS
EFEGELADDLAGFYRSEYMEGNVRKVVATTQMQAADARKSFPCFDEPAMKAEFNITLIHP
KDLTALSNMLPKGPSTPLPEDPNWNVTEFHTTPKMSTYLLAFIVSEFDYVEKQASNGVLI
RIWARPSAIAAGHGDYALNVTGPILNFFAGHYDTPYPLPKSDQIGLPDFNAGAMENWGLV
TYRENSLLFDPLSSSSSNKERVVTVIAHELAHQWFGNLVTIEWWNDLWLNEGFASYVEYL
GADYAEPTWNLKDLMVLNDVYRVMAVDALASSHPLSTPASEINTPAQISELFDAISYSKG
ASVLRMLSSFLSEDVFKQGLASYLHTFAYQNTIYLNLWDHLQEAVNNRSIQLPTTVRDIM
NRWTLQMGFPVITVDTSTGTLSQEHFLLDPDSNVTRPSEFNYVWIVPITSIRDGRQQQDY
WLIDVRAQNDLFSTSGNEWVLLNLNVTGYYRVNYDEENWRKIQTQLQRDHSAIPVINRAQ
IINDAFNLASAHKVPVTLALNNTLFLIEERQYMPWEAALSSLSYFKLMFDRSEVYGPMKN
YLKKQVTPLFIHFRNNTNNWREIPENLMDQYSEVNAISTACSNGVPECEEMVSGLFKQWM
ENPNNNPIHPNLRSTVYCNAIAQGGEEEWDFAWEQFRNATLVNEADKLRAALACSKELWI
LNRYLSYTLNPDLIRKQDATSTIISITNNVIGQGLVWDFVQSNWKKLFNDYGGGSFSFSN
LIQAVTRRFSTEYELQQLEQFKKDNEETGFGSGTRALEQALEKTKANIKWVKENKEVVLQ
WFTENSK
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| BDBM50415632 |
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| n/a |
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| Name | BDBM50415632 |
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| Synonyms: | CHEMBL1077586 |
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| Type | Small organic molecule |
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| Emp. Form. | C41H56N8O8 |
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| Mol. Mass. | 788.9321 |
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| SMILES | CCCC[C@H](N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(O)=O |r| |
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| Structure | 
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