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TargetHistamine H4 receptor
LigandBDBM50415770
Substrate/Competitorn/a
Meas. Tech.ChEMBL_615000 (CHEMBL1116877)
Ki 1.45±n/a nM
Citation Koenig, JRLiu, HDrizin, IWitte, DGCarr, TLManelli, AMMilicic, IStrakhova, MIMiller, TREsbenshade, TABrioni, JDCowart, M Rigidified 2-aminopyrimidines as histamine H4 receptor antagonists: effects of substitution about the rigidifying ring. Bioorg Med Chem Lett20:1900-4 (2010) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Histamine H4 receptor
Name:Histamine H4 receptor
Synonyms:HH4R | HRH4_RAT | Hrh4
Type:G Protein-Coupled Receptor (GPCR)
Mol. Mass.:44045.07
Organism:Rattus norvegicus (rat)
Description:Cell pellets from SK-N-MC cells transfected with rat H4 receptor were used in binding assay.
Residue:391
Sequence:
MSESNGTDVLPLTAQVPLAFLMSLLAFAITIGNAVVILAFVADRNLRHRSNYFFLNLAIS
DFFVGVISIPLYIPHTLFNWNFGSGICMFWLITDYLLCTASVYSIVLISYDRYQSVSNAV
RYRAQHTGILKIVAQMVAVWILAFLVNGPMILASDSWKNSTNTEECEPGFVTEWYILAIT
AFLEFLLPVSLVVYFSVQIYWSLWKRGSLSRCPSHAGFIATSSRGTGHSRRTGLACRTSL
PGLKEPAASLHSESPRGKSSLLVSLRTHMSGSIIAFKVGSFCRSESPVLHQREHVELLRG
RKLARSLAVLLSAFAICWAPYCLFTIVLSTYRRGERPKSIWYSIAFWLQWFNSLINPFLY
PLCHRRFQKAFWKILCVTKQPAPSQTQSVSS
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50415770
n/a
NameBDBM50415770
Synonyms:CHEMBL1079516
TypeSmall organic molecule
Emp. Form.C16H25N5
Mol. Mass.287.4032
SMILESCNC1CN(C1)c1nc(N)nc2c1CCCC21CCCC1
Structure
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