Ki Summary BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetSubstance-K receptor
LigandBDBM50415942
Substrate/Competitorn/a
Meas. Tech.ChEMBL_633592 (CHEMBL1120420)
Ki 0.316±n/a nM
Citation Fattori, DPorcelloni, MD'Andrea, PCatalioto, RMEttorre, AGiuliani, SMarastoni, EMauro, SMeini, SRossi, CAltamura, MMaggi, CA Structure-activity relationships of 6-methyl-benzo[b]thiophene-2-carboxylic acid (1-[(S)-1-benzyl-4-[4-(tetrahydropyran-4-ylmethyl)piperazin-1-yl]butylcarbamoyl]cyclopentyl)amide, potent antagonist of the neurokinin-2 receptor. J Med Chem53:4148-65 (2010) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Substance-K receptor
Name:Substance-K receptor
Synonyms:NK-2 receptor | NK-2R | NK2R | NK2R_HUMAN | NKNAR | Neurokinin 2 receptor | Neurokinin A receptor | Neurokinin NK2 | Neurokinin-2 (NK-2) | Neuromedin-2 receptor (NK-2R) | SKR | TAC2R | TACR2 | Tachykinin receptor 2 | Tachykinin receptor 2 (NK2) | hnk-3
Type:Protein
Mol. Mass.:44455.78
Organism:Homo sapiens (Human)
Description:P21452
Residue:398
Sequence:
MGTCDIVTEANISSGPESNTTGITAFSMPSWQLALWATAYLALVLVAVTGNAIVIWIILA
HRRMRTVTNYFIVNLALADLCMAAFNAAFNFVYASHNIWYFGRAFCYFQNLFPITAMFVS
IYSMTAIAADRYMAIVHPFQPRLSAPSTKAVIAGIWLVALALASPQCFYSTVTMDQGATK
CVVAWPEDSGGKTLLLYHLVVIALIYFLPLAVMFVAYSVIGLTLWRRAVPGHQAHGANLR
HLQAMKKFVKTMVLVVLTFAICWLPYHLYFILGSFQEDIYCHKFIQQVYLALFWLAMSST
MYNPIIYCCLNHRFRSGFRLAFRCCPWVTPTKEDKLELTPTTSLSTRVNRCHTKETLFMA
GDTAPSEATSGEAGRPQDGSGLWFGYGLLAPTKTHVEI
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM50415942
n/a
NameBDBM50415942
Synonyms:CHEMBL1083871
TypeSmall organic molecule
Emp. Form.C37H45N5O2S
Mol. Mass.623.851
SMILESCc1ccc2cc(sc2c1)C(=O)NC1(CCCC1)C(=O)N[C@@H](CCCN1CCN(Cc2cccnc2)CC1)Cc1ccccc1 |r|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: